Publications by authors named "Nripendra Acharya"

Many of the existing composite social determinant of health indices, such as Area Deprivation Index, are constrained by their reliance on geographic approximations and American Community Survey data. This study builds on the body of literature around deprivation indices to construct an individual socioeconomic deprivation index (ISDI) within the NIH's All of Us Data Network by using weighted multiple correspondence analysis on SDOH data elements collected at the participant level. In this study, the correlation between ISDI and another area-approximated index is assessed to the extent possible, along with the changes in an AI models performance due to stratified sampling based on ISDI quintiles.

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Article Synopsis
  • The study addresses challenges in selecting computational phenotypes for research by proposing a novel metadata framework to improve retrieval and reuse of these phenotypes.
  • Twenty active researchers contributed to identifying 39 relevant metadata elements, which were then evaluated through surveys and annotation tasks involving type-2 diabetes mellitus phenotypes.
  • Results showed over 90% satisfaction with the framework's utility, highlighting effectiveness in phenotype description and validation, while noting challenges in data collection complexity and associated costs.
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The All of Us (AoU) Research Program aggregates electronic health records (EHR) data from 300,00+ participants spanning 50+ distinct data sites. The diversity and size of AoU's data network result in multifaceted obstacles to data integration that may undermine the usability of patient EHR. Consequently, the AoU team implemented data quality tools to regularly evaluate and communicate EHR data quality issues at scale.

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