Scope: Ferulic acid (FA), a natural phenolic phytochemical abundantly present in whole grains, herbs, and dried fruits, exhibits anti-inflammatory, antioxidant, and neuroprotective effects. In the present study, the antidepressant-like effects of FA in male ICR mice using tail suspension test (TST) are investigated and its molecular mechanisms are explored.
Methods And Results: Oral administration of FA at a dose of 5 mg kg for 7 days significantly reduces immobility of mice compared to vehicle-administered control group.