Publications by authors named "Nozomi Tokita"
Background: The usefulness of bronchoscopy for the diagnosis of NTM pulmonary disease (NTM-PD) has been reported. However, performing bronchoscopy for aspirated sputum and airway secretion specimens (sputum aspirate specimens) in the region extending from the trachea down to the orifice of each segmental bronchus has been poorly documented. We evaluated the diagnostic yield of sputum aspirate specimens collected from the central airway using bronchoscopy.
View Article and Find Full Text PDFArticle Synopsis
- Amikacin liposome inhalation suspension (ALIS) showed effectiveness in increasing sputum culture conversion rates in patients with refractory Mycobacterium avium complex pulmonary disease (MAC-PD) after 6 months of treatment in a phase 3 trial.
- A study involving 12 patients at Toho University revealed that 58.3% achieved culture conversion, with factors like shorter previous treatment duration and fewer cavitary lesions on chest CT linked to better outcomes.
- While improvements in chest CT findings were noted, they did not always match with culture conversion results, indicating that the correlation between imaging and treatment success is complex.
We herein report a case of Mycobacterium interjectum pulmonary disease (M. interjectum-PD) that improved considerably after azithromycin (AZM), rifampicin (RFP), and ethambutol (EB) therapy. A 69-year-old woman, managed locally for suspected NTM-PD based on chest computed tomography (CT) findings was referred to our hospital for worsening productive cough six years after the initial diagnosis.
View Article and Find Full Text PDFBackground: In Mycobacterium avium complex pulmonary disease (MAC-PD), diagnosis requires a positive culture from at least two separate expectorated sputum specimens. The optimal number of sputum examinations remains unclear.
Objective: This study sought to elucidate the diagnostic yield of acid-fast bacilli in MAC-PD using 3 sputum specimens and to clarify the clinical characteristics of patients with MAC-PD diagnosed using 3 sputum specimens.
Article Synopsis
- * A case study involved a 74-year-old woman whose MAC-PD treatment was ineffective, prompting further testing that revealed a co-infection, which was successfully treated with trimethoprim-sulfamethoxazole (TMP-SMX).
- * The findings emphasize that worsening chest CT results after adequate MAC-PD treatment may indicate other infections, highlighting the need to differentiate these conditions in immunocompetent patients.
Background: The impact of co-infection with other pathogenic microorganisms after initiation of treatment for Mycobacterium avium complex pulmonary disease (MAC-PD) has not been clearly described. This study sought to clarify the clinical outcomes of co-infection with MAC after antimycobacterial therapy for MAC.
Methods: Co-infection status was defined as the detection of pathogenic microorganisms other than MAC in at least two consecutive sputum cultures 6-24 months after initiation of treatment.