Publications by authors named "Nozomi Tagai"
Alzheimer's disease (AD) is a progressive neurodegenerative disease with accompanying perceptive disorder. We previously reported that decreasing levels of brain-derived neurotrophic factor (BDNF) promoted beta-amyloid (Aβ)-induced neuronal cell death in neuron-like differentiated SH-SY5Y (ndSH-SY5Y) human neuroblastoma cells in an AD mimic cell model. We investigated the neuroprotective effects of passion fruit seed extract (PFSE) and one of the main stilbene compounds, piceatannol, in an AD cell model using ndSH-SY5Y cells.
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- Alzheimer's disease is marked by harmful buildups of amyloid β and tau proteins, leading to neuronal death through various processes.
- In the study, human neuroblastoma cells were used to explore how different levels of brain-derived neurotrophic factor (BDNF) affect the toxicity of amyloid β, finding that low BDNF levels significantly hinder neurite growth and increase cell death.
- The findings suggest that the experimental system can be useful for understanding the molecular events in Alzheimer's progression and for identifying potential neuroprotective drugs.