[Cystic polyposis of the stomach (fundic gland polyps)--relationship to the absence of Helicobacter pylori infection and a therapy with drugs suppressing gastric acidity].

Background: Cystic gastric polyps (fundic gland polyps) have been diagnosed relatively frequently in recent years. The aim of the study was to assess their incidence and relation to possible etiological factors reported in the literature.

Material And Methods: Over a 5 year period, we have endoscopically and histologically proved cystic polyps in 32 patients.

Changing prevalence of some selected gastrointestinal diseases vis-à-vis H. pylori infection.

Background/aims: The aim of this prospective study was to evaluate the changing relative prevalence of peptic ulcer disease, gastroesophageal reflux disease and functional dyspepsia over 18 years (four periods) in a country with a significant decline of H. pylori prevalence.

Methodology: In total, 3000 patients were studied.

[Nodular faciitis--rare localization on the eye (a case report)].

Goal: To contribute to differential diagnosis of changes of the outer segment of the eye.

Case Report: A 43-years old woman with three weeks long history of fast growing painless focus in the nasal part of the sclera of the left eye, which caused, except of visible tubercle and moderate feeling pressure, no problems. It is an unusual localization of non-malignant disease of unknown etiology originating from the Tenon's capsule.

Intravascular large B-cell lymphoma presenting as cutaneous panniculitis.

In this report the case of intravascular large B-cell lymphoma (angiotropic lymphoma, intravascular angioendotheliomatosis, malignant endotheliomatosis) with panniculitis features is present. The diagnosis was based on finding of typical CD20 positive tumorous cells within capillaries, veins, and small arteries in the biopsy of subcutaneous adipose tissue. An accurate and early diagnosis together with combined chemotherapy resulted in good response and remission of the disease.

[Giant myelolipoma of the adrenal gland].

Introduction: Myelolipoma is a rare benign tumor of adrenal gland, composed from a fatty tissue and hematogenous elements. It may be associated with endocrine disorders such as androgyneity, Cushing's disease, Addison's disease and other causes including obesity. It may also occur as a soft-tissue mass in various regions, especially in the area of small pelvis.

[Atheromatous (cholesterol) embolization].

A case is presented of an 89-year-old woman who died following an operation for arterial embolism of the lower limb. The autopsy histology showed acute occlusion of a stenosed sclerotic femoral artery by thrombotic and atheromatous emboli. In addition, it showed chronic cholesterol crystal embolism in multiple small arteries of abdominal organs, particularly of the kidneys.

[Fetal rhabdomyoma of the mucosa of the lip (case report)].

In a 15-year-old male the foetal type of rhabdomyoma was diagnosed in the mucosa of the lower lip. Diagnosis of this relatively rare tumour prevents possible mistaking for a malignant process and an inadequate therapeutic procedure.

Sclerosing papillary carcinoma of the thyroid with tubular features.

A case of papillary thyroid carcinoma (PTC) in a twenty-seven year old female is reported. The patient presented with complaints of a goiter and associated dysphagia. Histologically, the tumor was characterized by diffuse growth of branching tubules lined by a single layer of the tumor cells and surrounded by circularly arranged fibrous tissue of variable thickness.

[Aberrant mammae, personal experience].

The authors present information of a group of 63 patients (60 women and 3 men) treated in 1976-1998 where supernumerous aberrant or accessory mammary gland tissue was found. The diagnosis in the majority of the patients was based on histological examination. The tissue of an aberrant mammary gland is subject to the same physiological influences as the mamma proper and can be affected by the same pathological processes--benign and malignant.

[Calciphylaxis in a patient on long-term dialysis].

Calciphylaxis is a special form of soft tissue calcification (in particular blood vessels), affecting specially patients with chronic renal insufficiency and associated secondary hyperparathyroidism. Most severely affected are small arteries with a diameter of 0.2-0.

[Paratesticular spindle cell embryonal rhabdomyosarcoma in a 50-year-old man (case report)].

Spindle cell subtype of embryonal rhabdomyosarcoma in paratesticular region was diagnosed in a 50 year-old man. This relatively rare entity was constituted in 1992 and observed but in children up to now.

[Multiple Non-ossifying Fibroma (Case-report).].

The authors present the case-history of a patient with multiple non-ossifying fibroma causing pathological fractures in the long bones of the lower extremities, the vertebral bodies, ribs and bones of the brachial plexus. Since 1988 when the first pathological fracture occurred up to the present time when the tumour was found at other sites five biopsies of foci were made, all with the same histological finding. The pathological fracture in the distal portion of the right femur and the proximal portion of the left femur were treated by osteosynthesis and filled with bone cement.

[Helicobacter pylori eradication in patients with diseases of the stomach].

The authors present a review of contemporary findings concerning treatment of gastroduodenal ulcers with a positive finding of Helicobacter pylori. Only combined anti-Helicobacter treatment leads to the eradication of Helicobacter pylori in 80-96% of the patients. Moreover it leads to gradual recovery from gastritis and bulbitis and thus prevents ulcer recurrence.

Cytoplasmic inclusions in neocortical astrocytes associated with arteriopathic encephalopathy and dementia.

We describe what we believe to be the fifth case of a degenerative condition of the brain characterized by unusual intracytoplasmic inclusions in neocortical astrocytes, and we review four previous reports of what appears to be the same condition. Whereas these previous cases were characterized by prolonged clinical mental and psychomotor retardation, our case describes a rapid onset in a previously fit and mentally able patient in whom the astrocytic inclusions showed a close association with fibrohyaline vascular degeneration and changes resembling those of Alzheimer's disease. The inclusions, which were most frequent in the second to fourth layers of the frontal, temporal, and occipital cortices but absent from subcortical regions, consisted of large, irregular hyaline bodies surrounding the nucleus and extending into the proximal parts of cell processes.

The immunofluorescence evaluation of some subepidermal bullous diseases by use of NaCl-split skin.

Authors described the results of immunohistological investigation in 13 patients--12 with clinical diagnosis of bullous pemphigoid and 1 patient with clinical diagnosis of epidermolysis bullosa acquisita. 1 M NaCl solution was used to split normal human skin, used as substrates for immunohistological testing of the antilamina lucida and anti-sublamina densa antibodies.

[Helicobacter pylori in the etiology of ulcer disease and gastritis].

Helicobacter pylori (Hp) is unequivocally the most frequent cause of antral gastritis and most probably participates in the majority of cases in the aetiology of gastritis affecting the body of the stomach. The close relationship between antral gastritis and duodenal ulceration is documented by the high incidence of Hp in these patients (90-100%). The problem of Hp negative cases of duodenal ulceration was not finally resolved yet.

[Thymoma in the anterior mediastinum and systemic lupus erythematosus].

The authors describe an observation of a thymoma and systemic lupus erythematosus (SLE) in a 48-year-old woman with an analysis of clinical and laboratory indicators justifying this diagnosis. Improvement of SLE and the lupus nephropathy was achieved by three pulses of methyl prednisolone à 1000 mg in an intravenous infusion with subsequent Prednisone therapy, using conventional doses. After thymectomy on account of a benign thymoma activation of SLE did not occur.

[Pathologico-anatomic contribution to antibody detection in immunopathologic diseases].

Results of twenty years experience with identification of anti organ autoantibodies occurring mainly during autoimmune diseases are presented. Cryostat sections from human cadaver tissue and albino-rat kidneys were used for the detection of the above mentioned antibodies, by method of two-step (indirect) immunofluorescence. The study describes working schedule of a newly established subspeciality of pathological anatomy--the "histoserology".

Specific cellular immune response in patients with Helicobacter pylori infection.

The leukocyte migration inhibition test was performed in 39 patients with Helicobacter pylori infection and in 38 patients without such infection. The culture of Helicobacter pylori was used as antigen. A highly significant inhibitory effect on leukocyte migration was found in patients with Helicobacter pylori infection.

[Antibodies to basal cells of the parotid duct].

The use of indirect immunofluorescence technique confirmed the existence of spontaneous human auto-antibodies attaching to the basal cells in the excretory parotid duct. Analogically with literary data, based on the study of monoclonal antibodies, the author's opinion is that this is an auto-antibody with an unexpectedly narrow spectrum of specifically confined to antigen of cytokeratin polypeptides 13 and 16.

Immunological aspects of diagnosis of celiac sprue in children.

Serum anti-gluten (AGA) and anti-reticulin (ARA) antibodies were examined in children suffering from celiac sprue (CS); cellular hypersensitivity to gluten was tested and secretion of immunoglobulins and anti-gluten antibodies into the culture medium after 24-hour in vitro cultivation of jejunal mucosal biopsies was investigated with the aim to assess significance of these methods for CS diagnosis. Indirect immunofluorescence was used in ARA determination, ELISA method for AGA determination, cellular hypersensitivity was examined using the test of leucocyte migration inhibition (LMIT) with gluten. ARA were detected in 69% of children with untreated CS and in 28% of CS children who were on a gluten-free diet.