[Correction by succinic acid of behavioral and physiological parameters of neurosis-like condition in white rats].

The neurosis-like state of white rats is accompanied by development of cerebral hypoxia. Negative symptoms of the neurosis-like state (behavioral, anatomic and energy) were decreased by per os administration of succinate (30 mg/kg) during the second half of the neurotization process. Succinate provided chiefly the delayed action on the system arterial tension, on the succinate dehydrogenase and NADH dehydrogenase activity.

[The protective action of negative air ions in acute stress in rats with different typological behavioral characteristics].

Exposure of rats during immobilization to negatively charged air ions prevented the development of pathological changes typical for acute stress. Such protective action of negative air ions was observed in all the experimental animals independently of their types of behavior.

[The action of the neurotoxin AF64A on the reactions of neuroticized rats].

The effects of intracerebroventricular administration of ethylholine aziridinum ion (AF64A) were studied in neuroticized male Wistar rats. The cholinotoxin was bilaterally injected in the dose of 3 nmol. AF64A produced a significant decrease in arterial pressure and activity of respiratory enzymes succinate dehydrogenase and NADH-dehydrogenase in hippocampus and motor cortex.

[The prophylactic effect of negatively charged air ions in acute stress in rats with different typological behavioral characteristics].

Typological characteristics of behaviour of 63 male white rats weighing 200-250 g were estimated by their locomotion in the open field. Acute stress was induced by putting the rats into narrow tubes for 1 h. Prior to the experiment, the rats were exposed to the air ions produced by Chizhevskiĭ air ionizer ("Elion-132") for 2 h daily within a week.

[The normalizing effect of air ions on neuroticized rats with different typological behavioral characteristics].

The work was carried out in 98 white male rats weighting 200-250 g. Typological properties of behaviour were estimated by locomotor activity in the open field. Neurosis was induced by electro-pain irritation (15 min daily during 3 weeks), accompanied by the white noise (4 h daily).

[Effect of substance P on survival of rats after cerebral ischemia: the effect depends on behavior type].

In rats with different behaviour types in tests of "open field" and "forced swimming", influence of intraperitoneal administration of P-substance (PC) neuropeptide to survival and structural-metabolic changes in brain after double-sided ligating of carotid arteries. It was established that PC exerts different influence on stability to circulating cerebral hypoxia according to behaviour types: it increases stability in rats with passive behaviour type, decrease stability in rats with active behaviour type and does not influence on rats with middle behaviour type. Results shows the necessity of individual approach to peptide use with the view to increase stabilization to cerebral ischemia.

[The interrelation between individual behavioral characteristics and the indices of brain energy metabolism in rats].

In rats with active type of behaviour in "open field" and "forced swimming" tests in response to weak stress (handling) both the rate of local blood flow (RLBF) and free oxygen tension level (pO2) in the brain are increased, and in rats with passive type of behaviour RLBF is increased, but the pO2 level is decreased. The character of pO2 level changes in the brain under stress is significantly (r = -0.74, p less than 0.

[Pharmacological correction of experimental alcoholic embryopathy].

In the experiments on the progeny of ethanol-exposed rats it was shown that consumption of 15% alcohol instead of water during pregnancy resulted in the worsening of shuttlebox avoidance learning and decrease in succinate dehydrogenase activity in the visual and sensorimotor cortex. These data are indicative of cerebral hypoxia during embryogenesis. The injection of synthetic opioid peptide dalargin during critical periods of development (at the end of embryogenesis and early ontogeny) prevented partially the disturbances of higher nervous activity and tissue breathing which were induced by alcohol intoxication.

[A method of recording the gastric secretory function in mice].

The technique of simultaneous study of stomach functions and the secretory levels of its glands was developed on the CC57W/MvY mice using morphological, bio- and histochemical methods. Protein RNA, DNA contents and levels of gastric tissue SDH activity as well as the composition of the gastric juice were studied. The correlation of gastric secretion with the activity of its tissue SDH was demonstrated.

Clinical and electromyographic characteristics of pathological muscular-fatigue syndromes of the myasthenia type.

For many years myasthenia was classed among the rare neurological diseases. At the present time, because of an improvement in diagnosis and, possibly also because this disease has become widespread, the number of cases recorded has appreciably increased and comprises more than 3 per 100,000 population [1, 2]. More than 200 myasthenia patients are under our observation.

[Electromyographic and morphological analysis of the changes in the motor units in myasthenia, combined myasthenia with thymoma and polymyositis and terminal polyneuropathy with myasthenic syndrome].

Changes of the activity potentials of motor units and muscular fibres registered with the aid of needle electrodes are compared with the results of morphological examinations of biopsy specimens of 1,096 muscles taken from 137 patients with myasthenia, combinations of myasthenia with thymoma and polymyositis, as well as from patients with terminal polyneuropathy with the myasthenic syndrome. It has been shown that characteristic of myasthenia are differentiated changes of the motor unit activity potentials: in half of the muscles examined the parameters of those potentials were found to be normal, no polyphasic or protracted potentials were observed. In the patient with combinations of myasthenia with thymoma, polymyositis, and in terminal polyneuropathy with the myasthenic syndrome pronounced changes of all the activity potentials of the motor units were observed in the form of both a sharp shortening and a prolongation of their duration; a great number of polyphasic potentials was registered and spontaneous activity of various degree was observed.

[Clinical and electromyographic characteristics of syndromes of pathologic muscular fatigue of the myasthenic type].

On the basis of the follow-up study of more than 2000 patients with different forms of pathological muscular fatiguability of the myasthenic type, the authors emphasize the heterogeneity of this group of patients. The detailed study of clinical and electromyographic picture permitted them to distinguish the following clinical forms; myasthenia, myasthenic syndrome in terminal polyneuropathy, the myastheniapolymyositis complex, myasthenic syndrome of Lambert--Etone type.