Loop diuretic down-titration in stable chronic heart failure is often achievable, especially when urinary chloride concentration is low.

Background: This study investigates spot urinary chloride concentration in euvolemic chronic heart failure (CHF) patients.

Methods: This prospective cohort study included 50 ambulatory CHF patients on maintenance loop diuretics without recent hospital admission, clinical signs of volume overload, or adjustment in neurohumoral blocker or diuretic therapy. Spot urinary samples were collected immediately after loop diuretic intake.

Conduction disorder and QT prolongation secondary to long-term treatment with chloroquine.

A patient with polymorphic ventricular tachycardia, long QT interval and conduction disorders secondary to long-term treatment with chloroquine is presented.