Publications by authors named "Noya Shilo"
Background: The decision to allocate hospitals for the initial reception of hostages abducted on the October 7th Hamas attack introduced an array of unprecedented challenges. These challenges stemmed from a paucity of existing literature and protocols, lack of information regarding captivity conditions, and variability in hostage characteristics and circumstances.
Objective: To describe the rapid development, implementation and evaluation of the Hostage-ReSPOND protocol, a comprehensive trauma-informed procedure for the care of hostages, including young children, their caregivers and families, immediately following their release from prolonged captivity.
Background: At the beginning of 2020, the coronavirus disease 2019 (COVID-19) pandemic presented a new burden on healthcare systems.
Objectives: To evaluate the impact of the COVID-19 pandemic on the outcome of non-COVID patients in Israel.
Methods: We conducted a retrospective observational cohort study at a tertiary medical center in Israel.
Article Synopsis
- The study examines the prevalence of heparin-induced thrombocytopenia (HIT) in critically ill COVID-19 patients, finding a significant association with severe clinical outcomes.
- Out of 107 patients, over half experienced thrombocytopenia, leading to complications such as increased ventilation needs, disseminated intravascular coagulation (DIC), and higher mortality rates.
- The research suggests that understanding HIT's role in COVID-19 is crucial due to its impact on immune response and coagulopathy, highlighting the need for precise treatment protocols.
Background: Autoimmune neutropenia (AIN) is divided into primary and secondary forms. The former is more prevalent in children and is usually a self-limiting disease. Secondary AIN is more common in adults and often occurs in the setting of another autoimmune disorder or secondary to infections, malignancies or medications.
View Article and Find Full Text PDFAs the coronavirus pandemic emerged in late 2019, a task force was founded in the Sheba Medical Center and began preparing for the arrival of the pandemic to Israel. Several wards were put in charge of isolated COVID-19 patients. A new intensive care unit was formed for the most critical COVID-19 patients, requiring mechanical ventilation and multi-organ treatment.
View Article and Find Full Text PDFAmong patients with Coronavirus disease (COVID-19), the ability to identify patients at risk for deterioration during their hospital stay is essential for effective patient allocation and management. To predict patient risk for critical COVID-19 based on status at admission using machine-learning models. Retrospective study based on a database of tertiary medical center with designated departments for patients with COVID-19.
View Article and Find Full Text PDFArticle Synopsis
- Panobinostat, a pan-histone deacetylase inhibitor, shows promise in treating multiple myeloma (MM) but is ineffective alone, leading this study to explore the mechanisms of MM's resistance.
- The study found that lower levels of the CXCR4 chemokine receptor made MM cells more sensitive to panobinostat, while increased CXCR4 levels contributed to resistance due to activation of the mTOR survival pathway.
- Combining panobinostat with the mTOR inhibitor everolimus not only overcame this resistance but also enhanced cell death and targeted resistant MM cells effectively in vivo, suggesting a new therapeutic strategy for treating the disease.