Bleeding Complications of Anticoagulation Therapy in Clinical Practice-Epidemiology and Management: Review of the Literature.

Due to their very wide range of indications, anticoagulants are one of the most commonly used drug groups. Although these drugs are characterized by different mechanisms of action, the most common complication of their use is still bleeding episodes, the frequency of which depends largely on the clinical condition of the patient using such therapy. For this reason, to this day, the best method of preventing bleeding complications remains the assessment of bleeding risk using scales such as HAS-BLED.

Boldness, meanness and disinhibition as predictors of indirect/direct type of aggressive behavior in youth.

Objectives: Numerous studies show that a high level of psychopathic traits in youth is related to the propensity to use various types and forms of aggression. The presented study focuses on the relations between psychopathy and aggression, both indirect (relational) and direct in this age group. The triarchic model of psychopathy was used, according to which psychopathy is described as a configuration of boldness, meanness and disinhibition.

Contrasting responses of Thermocyclops crassus and T. oithonoides (Crustacea, Copepoda) to thermal stress.

Thermal tolerance is a critical factor influencing the survival of living organisms. This study focuses on the thermal resistance of copepod species, Thermocyclops crassus (Fischer, 1853) and T. oithonoides (Sars G.

Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19.

Despite extensive research, the specific factor associated with SARS-CoV-2 infection that mediates the life-threatening inflammatory cytokine response in patients with severe COVID-19 remains unidentified. Herein we demonstrate that the virus-encoded Open Reading Frame 8 (ORF8) protein is abundantly secreted as a glycoprotein and in symptomatic patients with COVID-19. ORF8 specifically binds to the NOD-like receptor family pyrin domain-containing 3 (NLRP3) in CD14 monocytes to induce inflammasomal cytokine/chemokine responses including IL1β, IL8, and CCL2.

Responding to stakeholder needs to engage rehabilitation professionals in the delivery of evidence-based health programming for adults with osteoarthritis.

Although there are many evidence-based programs that promote healthy lifestyles and symptom modification for people with osteoarthritis, their delivery in rehabilitation clinical settings in the United States is limited. These programs can be a primary component of treatment or a discharge option to facilitate long-term mobility and pain management. The purpose of this perspective article is to describe a delivery model that brings one arthritis-appropriate, evidence-based intervention, the Arthritis Foundation's Walk With Ease program, to older adults seeking physical therapy related to their osteoarthritis.

Assessing the effect of multiple variables on the production of bioflocculant by Serratia marcescens: Flocculating activity, kinetics, toxicity, and flocculation mechanism.

Bioflocculants gain attention as alternatives to chemical flocculants because they are more environmentally friendly and highly biodegradable. This study aims to improve the bioflocculant production by Serratia marcescens using one-variable-at-a-time (OVAT) analysis and analyze its flocculating activity performance, toxicity, and the flocculation mechanism. The effect of multiple variables including initial inoculum size, pH, mixing speed, temperature, growth medium, and incubation period was assessed through OVAT.

Badger as Ecosystem Engineer and Its Legal Status in Europe.

The European badger plays an important role as a natural factor shaping species diversity in forests. Its extensive setts can be used by many other animals as shelters. Soil perturbations in their setts support plant communities that differ from the matrix landscape.

Psychopathic traits, psychological resilience and coping with stress in socially maladjusted youth.

Objectives: The basic aim of the research was to analyze the associations between the traits of psychopathy in the triarchic model (boldness, meanness, disinhibition) and the level of psychological resilience and preferred style of coping with stress in the group of adolescents violating legal norms. The author assumes that the key symptoms in this relationship would be played by the symptoms of psychopathy included in the dimension of boldness.

Methods: The group of participants consisted of 111 girls and boys aged 16-18 years staying in youth correctional facilities.

Sustained, complete response to pexidartinib in a patient with CSF1R-mutated Erdheim-Chester disease.

Erdheim-Chester disease (ECD) is a histiocytic neoplasm that predominantly harbors mitogen-activated protein kinase (MAPK) pathway variants. MAPK inhibitors typically are effective treatments, but mutations outside the MAPK pathway, such as CSF1R variants, may cause refractory ECD. We describe a patient with a novel somatic mutation in CSF1R (CSF1R ) that resulted in refractory ECD affecting the central nervous system.

Long Arm of Motorway-The Impact of Fenced Road on the Mortality of European Badgers.

We studied the impact of the new fenced and accident-safe motorway on the mortality of European badgers Meles meles on local roads in western Poland in 2010-2015. We monitored the badgers mortality on local roads of three categories: main roads, secondary roads and county roads. The study was conducted before and after the opening of the motorway in 2012.

Short-term heat shock perturbation affects populations of Daphnia magna and Eurytemora carolleeae: a warning to the water thermal pollution.

Thermal pollution leads to short-term heat shock in aquatic invertebrates; however, the modulation of tolerance and life history of these invertebrates by thermal stress varies among regions, phenology, species, and their acclimation. To assess the effect of thermal shock, we conducted experiments on Daphnia magna and Eurytemora carolleeae at 25 °C, 30 °C, 35 °C, and 40 °C (in relation to 20 °C) in a different exposure time of the stressor (10, 30, and 60 min). The results showed that short-term heat shock leads to increased mortality and reduced fertility of the studied planktonic crustaceans.

MCIR1: A patient-derived mantle cell lymphoma line for discovering new treatments for ibrutinib resistance.

Background: Despite the unprecedented success of ibrutinib in lymphoma therapy, the development of ibrutinib resistance due to acquired BTK or PLCγ2 mutations has become a new clinical problem. However, not all resistance is mediated by these mutations and these mechanisms are poorly understood due to a lack of study tools that truly recapitulate this clinical scenario.

Methods: We established a novel patient-derived ibrutinib-resistant mantle cell lymphoma (MCL) line named MCIR1.

Directed, Elliptic, and Higher Order Flow Harmonics of Protons, Deuterons, and Tritons in Au+Au Collisions at sqrt[s_{NN}]=2.4 GeV.

Flow coefficients v_{n} of the orders n=1-6 are measured with the High-Acceptance DiElectron Spectrometer (HADES) at GSI for protons, deuterons, and tritons as a function of centrality, transverse momentum, and rapidity in Au+Au collisions at sqrt[s_{NN}]=2.4  GeV. Combining the information from the flow coefficients of all orders allows us to construct for the first time, at collision energies of a few GeV, a multidifferential picture of the angular emission pattern of these particles.

Underground diversity: Uropodina mites (Acari: Mesostigmata) from European badger (Meles meles) nests.

Badgers can gather huge quantities of organic material to build their nests for winter time and to rear their cubs. Moreover, badger burrows (setts) are characterized by specific microclimate with quite stable temperature and humidity. Their fauna is poorly studied, especially in respect of saprobiontic Uropodina mites.

Reproduction success in European badgers, red foxes and raccoon dogs in relation to sett cohabitation.

The setts of the European badger Meles meles can be cohabited during reproductive season by the red fox Vulpes vulpes and raccoon dog Nyctereutes procyonoides. There is no information on the possible impact of both species on the size of badgers' litter. The aim of the study was to show the influence of cohabitation of the same setts by badger, raccoon dog and fox on the litter size.

Science-graphic art partnerships to increase research impact.

Graphics are becoming increasingly important for scientists to effectively communicate their findings to broad audiences, but most researchers lack expertise in visual media. We suggest collaboration between scientists and graphic designers as a way forward and discuss the results of a pilot project to test this type of collaboration.

Strong Absorption of Hadrons with Hidden and Open Strangeness in Nuclear Matter.

We present the first observation of K^{-} and ϕ absorption within nuclear matter by means of π^{-}-induced reactions on C and W targets at an incident beam momentum of 1.7  GeV/c studied with HADES at SIS18/GSI. The double ratio (K^{-}/K^{+})_{W}/(K^{-}/K^{+})_{C} is found to be 0.

Targeting glycogen synthase kinase 3 for therapeutic benefit in lymphoma.

Targeting the B-cell receptor and phosphatidylinositol 3-kinase/mTOR signaling pathways has shown meaningful, but incomplete, antitumor activity in lymphoma. Glycogen synthase kinase 3 (GSK3) α and β are 2 homologous and functionally overlapping serine/threonine kinases that phosphorylate multiple protein substrates in several key signaling pathways. To date, no agent targeting GSK3 has been approved for lymphoma therapy.

Managing the Unimaginable: Biobank Participant Views on Reconsent for Whole Genome Sequencing of Stored Biospecimens.

DNA biobanks frequently obtain broad permissions from sample donors, who agree to allow their biospecimens to be used for a variety of future purposes. A limitation of this approach is that it may not be possible to discuss or anticipate all potential uses of biospecimens at the time patient consent is obtained. We surveyed biobank participants to clarify their views regarding the need to be informed about research involving whole genome sequencing (WGS).

Universal Fermi-Level Pinning in Transition-Metal Dichalcogenides.

Understanding the electron transport through transition-metal dichalcogenide (TMDC)-based semiconductor/metal junctions is vital for the realization of future TMDC-based (opto-)electronic devices. Despite the bonding in TMDCs being largely constrained within the layers, strong Fermi-level pinning (FLP) was observed in TMDC-based devices, reducing the tunability of the Schottky barrier height. We present evidence that metal-induced gap states (MIGS) are the origin for the large FLP similar to conventional semiconductors.

Control of the metal/WS contact properties using 2-dimensional buffer layers.

Transition metal dichalcogenides (TMDC) have recently attracted much attention as a promising platform for the realization of 2-dimensional (2D) electronic devices. One of the major challenges for their wide-scale application is the control of the potential barrier at the metal/TMDC junction. Using conductive atomic force microscopy (c-AFM) we have investigated modifications of the Schottky barrier height (SBH) across a Pt/WS2 junction by the introduction of thin buffer layers of graphene and MoSe2.