Nonlinear variability of body sway in patients with phobic postural vertigo.

Background: Subjective postural imbalance is a key symptom in the somatoform phobic postural vertigo (PPV). It has been assumed that more attentional control of body posture and / or co-contraction of leg muscles during standing is used to minimize the physiological body sway in PPV. Here we analyze nonlinear variability of body sway in patients with PPV in order to disclose changes in postural control strategy associated with PPV.

Comparative transcriptional profiling of the axolotl limb identifies a tripartite regeneration-specific gene program.

Understanding how the limb blastema is established after the initial wound healing response is an important aspect of regeneration research. Here we performed parallel expression profile time courses of healing lateral wounds versus amputated limbs in axolotl. This comparison between wound healing and regeneration allowed us to identify amputation-specific genes.

Inadequate interaction between open- and closed-loop postural control in phobic postural vertigo.

Phobic postural vertigo (PPV) is characterized by a subjective dizziness and postural imbalance. Changes in postural control strategy may cause the disturbed postural performance in PPV. A better understanding of the mechanisms behind this change in strategy is required to improve the diagnostic tools and therapeutic options for this prevalent disorder.

A new set of markers for human identification based on 32 polymorphic Alu insertions.

A number of genetic systems for human genetic identification based on short tandem repeats or single nucleotide polymorphisms are widely used for crime detection, kinship studies and in analysis of victims of mass disasters. Here, we have developed a new set of 32 molecular genetic markers for human genetic identification based on polymorphic retroelement insertions. Allele frequencies were determined in a group of 90 unrelated individuals from four genetically distant populations of the Russian Federation.

On the utility of short intron sequences as a reference for the detection of positive and negative selection in Drosophila.

The detection of selection, both positive and negative, acting on a DNA sequence or class of nucleotide sites requires comparison with a reference sequence that is unaffected by selection. In Drosophila, recent findings of widespread selective constraint, as well as adaptive evolution, in both coding and noncoding regions highlight the difficulties in choosing such a reference sequence. Here, we investigate the utility of short intron sequences as a reference for the detection of selection.

[On mechanism of nonlinear laser cleavage of DNA].

Dependences of nonlinear laser cleavage of DNA on a concentration of the free-radical scavenger, beta-mercaptoethanol, have been measured. The obtained data rule out the free-radical mechanism of the nonlinear laser cleavage and agree with the mechanism based on two-quantum excitation energy transfer from a dye to DNA. A high concentration of beta-mercaptoethanol has been found to cause DNA hyperchromicity.

[Neutralizing morbillivirus antibodies in the population of the Baikal seal Phoca sibirica].

The antibodies neutralizing Baikal seal morbillivirus (BSMV) were studied in sera from 148 normal Baikal seals (Phoca sibirica). The virus-neutralizing antibodies were demonstrated in sera of 61.5% of the animals examined.

[Ebola virus reproduction in cell cultures].

Ebola-Zaire virus production in Vero and BGM cells was studied. The CPE developed in both cell cultures. The cell monolayer destruction by 80-90% was seen at a low multiplicity of infection in 7-8 days after virus inoculation.

[An experimental infection of the seal Phoca sibirica with the morbilli virus].

A Baikal seal (Phoca sibirica) was experimentally infected with Baikal seal morbillivirus (BSMV) isolated from Baikal seals during an epizootic in 1987-1988. The seal was infected with BSMV with an infectious titer of 10(7.0) TCD50/ml, and daily observations of the animal clinical condition were made.

[The isolation and characteristics of continuous virus-producing lymphoid suspension cultures of African green monkey cells].

Five continuous lymphoid suspension cell cultures were established by cultivation of lymphocytes from African green monkeys. The immunological typing revealed the mixed pattern of cultures consisting of B and T cell types. Two types of viruses: herpesvirus and retrovirus C-type were demonstrated by electron microscopy.

[Comparative analysis of genomes of oncogenic B-lymphotropic herpesviruses reproducing in cell lines obtained from different monkey species].

The aim of this work was to study genomes of B-lymphotropic oncogenic herpesviruses of Macaca arctoides (HVMA), Papio hamadryas (HVP) and Cercopithecus aethiops (HVGM). Blot-hybridization detected inter- and intraspecific genome heterogeneity of investigated viruses in restriction sites EcoR1, Pst1 and Hind111. Virus-specific sequences in two-cell lines obtained from HVMA-induced rabbit tumours can prove HVMA a role in malignant tumour induction in rabbits.

[Nonlinear laser photomodification of nucleic acids induced by intercalating dyes].

Results of a cycle of investigations of two-quantum affinity modification of nucleic acids (NA) are presented. The modification is induced by laser excitation of chromophoric molecules which are in intercalative complexes with NA. The following subjects are considered: theoretical basis of the two-quantum affinity modification: experimental investigation of nonlinear scission of DNA; theory and experiment on the light--induced diffusion of DNA.