Protective Effects of Probiotics on Cognitive and Motor Functions, Anxiety Level, Visceral Sensitivity, Oxidative Stress and Microbiota in Mice with Antibiotic-Induced Dysbiosis.

Accumulating clinical and preclinical data indicate a prominent role of gut microbiota in regulation of physiological functions. The gut-brain axis imbalance due to gut dysbiosis is associated with a range of neurodegenerative diseases. Probiotics were suggested not only to restore intestinal dysbiosis but also modulate stress response and improve mood and anxiety symptoms.

A case of anti-VGKC antibody encephalitis and prolonged encephalopathy despite spontaneous resolution of imaging abnormalities.

Unlabelled: Anti-voltage-gated potassium channel (anti-VGKC) antibody encephalitis is a common form of autoimmune encephalitis (AE). AE is usually associated with autoimmune diseases or paraneoplastic phenomena such as seen in small cell lung cancer. Clinical presentation can include memory impairment, seizures, and psychiatric symptoms.

Acute diverticulitis masquerading as unilateral sciatica-like symptoms.

A 66 year-old female presented with Systemic Inflammatory Response Syndrome (SIRS), severe left thigh pain, and localized edema. Non-contrast Computed Tomography (CT) suggested the presence of air in the left thigh and no evidence of an acute intra-abdominal process. Blood cultures grew an anaerobic gram-negative microorganism identified as .

[Mechanisms of anti-inflammatory activity of antioxidants in lung tuberculosis].

The experiment on 120 non-inbred albino rats with induced pulmonary destructive tuberculosis has established that the antiinflammatory action of the antioxidant dibunol is displayed through changes in the ratio of biologically active 11-hydroxycorticosteroids--free hydrocortisone and corticosterone.

[The pro-fibrotic and pro-oxidant action of isoniazid].

As a result of experimental research on rats with destructive pulmonary tuberculosis, oxidative action of isoniazid in a dose of 50 mg per kg body weight, corresponding to the mean therapeutic dose of 10 mg/kg in man, was clearly defined. Fibrotic action of the drug was also shown. It manifested itself by a sharp rise of insoluble collagen levels in the lung tissue tuberculous lesion focus of the treated animals and in the formation of mature connective tissue.

[Indications for the use of prednisolone in tuberculosis].

To study the nature of lesions in the lungs developing as a result of using glucocorticoids in combined therapy of tuberculosis, two groups of new cases of infiltrative tuberculosis were observed. 51 patients were treated with the use of prednisolone and 23 patients were treated with antibacterial drugs alone. In addition, studies were performed on two groups of noninbred albino rats infected with mycobacteria Bovinus-8.

[Lung changes in rats under the action of paraquat and the importance of antioxidants].

Characteristic features of pulmonary lesions after exposure to paraquat and various antioxidants were studied in albino rats. The antioxidants included dibunol, sodium thiosulfate and its combination with alpha-tocoferol. In the treated animals, there was a marked decrease in the areas affected by atelectasis and lower severity of elastofibrosis, involution of the connective tissue evident from its thinner fascicles and destruction of the collagenous and elastic fibers.

[Effectiveness of soluble rifampicin in combination with other antibacterial preparations in treating disseminated destructive pulmonary tuberculosis in an experiment].

Efficacy of a new rifampicin dosage form developed at the All-Union Research Institute of Antibiotics was studied on dogs with extensive destructive tuberculosis of the lungs. Intracavernous instillation and rapid intravenous administration (RIA) of the drug in combination with 10 per cent solution of isoniazid and intramuscular administration of streptomycin were used. Intracavernous instillation of rifampicin in combination with 10 per cent solution of isoniazid was performed under the control of an x-ray unit with an image converter tube or with the developed administration procedure through an indwelling catheter.

[Complications and their elimination during the rapid intravenous administration of rifampicin in an experiment].

Reaction to rapid intravenous administration (RIA) of rifampicin in a dose of 10 mg/kg was studied on 173 healthy dogs. Immediately after the first RIA of rifampicin there were observed vomiting and ataxia of various levels in 5.2 per cent of the animals.

[Comparative effectiveness of the enteral and intravenous administration of rifampicin in treating experimental tuberculosis in rabbits].

The efficacy of intravenous and enteral administration of rifampicin was studied comparatively in treatment of hematogenic diseminated tuberculosis in rabbits. The drugs were administered in a dose of 10 mg/kg for 60 days. The functional state of the liver was studied in the time course by activity of urokinase, a hepatospecific enzyme and transaminases.

[Effectiveness of the rapid intravenous administration of rifampicin and isoniazid and of the intramuscular administration of streptomycin in disseminated destructive pulmonary tuberculosis in dogs].

Soluble rifampicin and isoniazid injected rapidly by the intravenous route and streptomycin injected intramuscularly to dogs with disseminated destructive tuberculosis of the lungs provided sterilization of the organs with respect to M. tuberculosis for the period of their use for 2 months. This was confirmed microbiologically.

[Effect of sodium thiosulfate on morphological manifestations of experimental tuberculosis].

The effect of an antioxidant, sodium thiosulphate (in doses of 100 and 150 mg/kg), on morphological manifestations of experimental tuberculosis was studied in 35 white rats. Sodium thiosulphate exerted a marked antiinflammatory and antisclerogenic effect. Changes in morphology (rearrangement of fibrous connective tissue into loose shapeless tissue with increased number of cell elements, mainly lymphocytes, and changes in the structure of collagen fibers down to granular degeneration) and typical properties of the connective tissues (decreased fuxinophilia, decreased content of proteoglycans and glycoproteins, appearance of picrinophilia) were observed in different periods of tuberculosis development which led to a conclusion that sodium thiosulphate not only partially prevented the crude fibrosis formation but also affected the already formed fibrous tissue by its resorption.

[Enhancement phenomenon in mice with a heterotopic heart transplant].

A possibility of enhancement induction with the aid of a preparation of lymphocyte membranes of the spleen of donor specificity in its combination with antimouse horse globulin was studied on mice with heterotopic graft of the heart. As shown, in recipients with prolongation of the graft electrical activity lymphocytes retained their reaction to donor antigens, whereas the blood serum produced an enhancement effect in its administration to syngeneic recipients.

In vitro and in viro effects of the fifth thymosin fraction.

Using the 5th fraction of thymosin, it was possible to enhance the capacities of peripheral blood lymphocytes to form rosettes with sheep erythrocytes and to respond to PHA in those cases of cancer or sarcoidosis in which these functions were depressed. Moreover, the 5th thymosin fraction increased the resistance of CBA mice to infection with virulent H37Rv mycobacteria and augmented their ability to acquire delayed hypersensitivity.