[Polymorphism of placental alkaline phosphatase on the level of DNA and protein in the Mordovian population].

Data on DNA and enzyme polymorphisms of human placental alkaline phosphatase (PLAP) in Mordvinian populations are presented. Restriction fragment length polymorphism (RFLP) was detected after the digestion of DNA samples with Rsa I and Pst I endounucleases. The frequencies of the second (2) allele for PLAP Pst I and Rsa I were 0.

[Genetic position of Mordvinians among other Finno-Ugrian peoples].

Two different tribes of Mordvinians, Erzia and Moksha, were studied with respect to 13 different genetic marker systems. The Erzia and Moksha were shown to be fairly homogeneous; a significant gene frequency difference was found only in the MN blood group system. Estimation of the genetic distances revealed that Mordvinians showed the closest relationship to the Maris and to populations of the western Finno-Ugrian linguistic group such as Finns, Estonians and Karelians.

[Feasibility of establishing genetic homeostasis in human populations using a complex of genetic markers].

The information that we have about functional connection of different phenotypes of independent loci served for identification of their reciprocal behavior in cohorts differed in healthy status from the same population. Coefficients of correlation were computed between phenotypes according to the scheme: everyone with all in a Buryat, on the basis of the distribution of 17 genetic loci. Their space was transformed to a standardized one of eigenvectors.

[An ecogenetic approach to studying the adaptation and human health].

Genetic markers--blood groups ABO, RH, MN; serum proteins HP, PI, TF, C3; erythrocyte enzymes ACP1, ESD, AK1, PGM1, GLO1, PGD, PGP; and the other: PTC-tasting, ear wax types and color vision, were studied in two aboriginal Buryatian populations of Baikal Lake region: in Chitinskaya and Irkutskaya Provinces. Two samples were further divided into subgroups, according to their health status: "healthy", "indefinite" and "sick" by means of special regression procedure. The "healthy" subgroup of the Chitinskaya Province population is characterized by higher frequencies of PTC-tasters: 0.

[Study of interlocus interactions using a series of gene markers in samples from groups with different health status].

Interloci equilibrium between pairs of gene markers in the samples of different health rate in the population of Buryats of Chitinskaya Province was tested. The following methods were used: calculation of interloci correlation coefficients, chi 2-testing of the hypothesis of interloci equilibrium and the modification of principal components analysis on the basis of the matrix of Pearson's coefficients of contingency. In the groups of "extreme" health rate the tendency to increase in interloci disequilibrium was discovered.

[Genetic polymorphism of the erythrocytic enzymes in the Buryat populations].

Polymorphism of seven erythrocytic enzymes PGM1, ESD, CLO1, PGD and PGP were studied in five samples of Buryats. The main investment into differentiation between populations has been made by the following systems: CLO1, PGD and PGM1. Analysis of genetic distances between populations demonstrated that there was some parallelism among the genetic and anthropological differentiation in the Buryat populations.

[Genetic studies of phosphoglucomutase-1 (PGM1) subtypes: population aspects].

Distribution of the subtypes and gene frequencies of phosphoglucomutase-1 among some populations of Buryats, Kirghizes of the Pamir and Russians of Moscow district was analysed. The frequencies of PGM1 genes vary in Buryats being PGM1+(1) 0.647-0.

[Possibilities of creating a genetic information database and its processing based on the DBase3-plus system].

Special methods are required for computing information on biological objects under complex research. The DBASE3-PLUS system offers vast possibilities for working with large quantity of different sets of information in multi-aspect statistical analysis. Usefulness of this system for creation of and operation with the data on distribution of genetic and non-genetic traits in a population was shown by means of the special set of applied programs in the dBase language.

[Polymorphism of alpha1-antitrypsin in Pamir populations. Reproductive compensation--possible mechanism for maintaining genetic diversity gor PI genes in human populations].

The distribution of the phenotype and gene frequencies of alpha 1-antitrypsin among Pamir's aborigines localized at high altitudes was studied. The Kirghizes of Murgab studied include mainly the mongoloid component in their composition. Populations of the Khuf river valley in West Pamir anthropologically belong to South caucasoids.