Publications by authors named "Novita Sariyanti"
Background: In Papua (Indonesia), infants with P. falciparum and/or P. vivax malaria are at risk of severe anaemia and death.
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- Asymptomatic infections of P. falciparum malaria in adults may hinder clinical immunity rather than support it, serving as a reservoir for the parasite and aiding its transmission.
- Researchers used a systems approach involving antibody responses and cell profiling to study the immune responses in individuals with symptomatic and asymptomatic malaria, linking certain immune cell profiles to a lower risk of clinical malaria.
- Findings indicate that while some immune responses exist, asymptomatic infections also promote immunosuppressive mechanisms that could undermine effective immune control and vaccine responsiveness against malaria.
Article Synopsis
- The study explores the complex role of IFN-γ in malaria, particularly its influence on T follicular helper cells and memory B cells, which are crucial for effective antibody responses and immunity.
- Through single-cell mass cytometry, distinct populations of CD4+ T cells with the T-bet factor were identified, showing varying risks for Plasmodium vivax malaria outcomes, indicating that inflammation can sometimes be beneficial.
- Additionally, specific types of memory B cells and T cell subsets were linked to reduced risk of symptomatic malaria, while others contributed to protection against asymptomatic infections, highlighting the need for both antibody and cell-mediated immunity in managing malaria.