Publications by authors named "Novita Ikbar Khairunnisa"
Article Synopsis
- H3K27 trimethylation (H3K27me3), regulated by EZH2, plays a critical role in gene expression and is a key diagnostic marker for certain brain tumors, but its implications in astrocytoma with IDH mutation are unclear.
- A study involving 33 patients analyzed the correlation between immunohistochemical markers (including H3K27me3, EZH2) and patient outcomes like overall survival (OS) and progression-free survival (PFS).
- Results indicated that H3K27me3 positivity, particularly when combined with EZH2 positivity, was associated with poorer survival rates, suggesting it may serve as a significant prognostic factor for astrocytoma, IDH
Introduction: The T2-FLAIR mismatch sign is a characteristic imaging biomarker for astrocytoma, isocitrate dehydrogenase (IDH)-mutant. However, investigators have provided varying interpretations of the positivity/negativity of this sign given for individual cases the nature of qualitative visual assessment. Moreover, MR sequence parameters also influence the appearance of the T2-FLAIR mismatch sign.
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- * Researchers analyzed MRI images from 31 cases from their institution and 30 cases from The Cancer Genome Atlas, finding that the super T2-FLAIR mismatch sign is associated with significantly improved progression-free survival (PFS) and overall survival (OS).
- * The results suggest that the super T2-FLAIR mismatch sign could serve as a valuable prognostic imaging biomarker for patients with this type of astrocytoma.
Article Synopsis
- Radiation therapy (RT) can improve cancer outcomes but also increases the risk of radiation-induced brain tumors (RIBTs), which include gliomas, meningiomas, and sarcomas in survivors.
- A comprehensive analysis of 957 patients revealed that younger patients (especially those under 5) have a higher risk for RIBTs, with median ages at irradiation being significantly lower for meningiomas compared to the other tumor types.
- Results showed a longer latency period for meningiomas (20 years) compared to gliomas (9 years) and sarcomas (10 years), and overall survival rates were significantly better for meningioma patients versus glioma and sarcoma patients, particularly following higher radiation doses.
Article Synopsis
- This study investigates the effectiveness of diffusion-weighted imaging (DWI) in predicting recurrence in primary central nervous system lymphomas (PCNSLs) among patients who show a complete response (CR) after treatment.
- The research included 54 patients divided based on the presence of residual DWI hyperintense signals, analyzing their survival outcomes, where those with residual signals had significantly shorter progression-free survival (PFS).
- Results indicated that the R-MPV chemotherapy regimen was linked to a lower incidence of residual DWI signals, suggesting that incorporating DWI evaluation could improve treatment monitoring in PCNSL patients.
Temozolomide is an oral alkylating agent with moderate side effects compared to other agents. However, the development of secondary malignancies following temozolomide has been reported. We describe the first case of primary central nervous system lymphoma (PCNSL) occurrence following glioblastoma treatment.
View Article and Find Full Text PDFBackground: Posttraumatic epilepsy (PTE) is a debilitating sequelae following traumatic brain injury (TBI). Risk of developing PTE is higher in the first 6 months following head trauma and remains increased for 10 years. Many cases of PTE developed into drug-resistant epilepsy in which need surgical treatment.
View Article and Find Full Text PDFTo share the experiences of organizing the epilepsy surgery program in Indonesia. This study was divided into two periods based on the presurgical evaluation method: the first period (1999-2004), when interictal electroencephalogram (EEG) and magnetic resonance imaging (MRI) were used mainly for confirmation, and the second period (2005-2017), when long-term non-invasive and invasive video-EEG was involved in the evaluation. Long-term outcomes were recorded up to December 2019 based on the Engel scale.
View Article and Find Full Text PDFThis 48-year-old-man who had undergone right thyroid lobectomy for undifferentiated thyroid carcinoma nine years earlier developed generalized seizures. His cerebrospinal fluid was xanthochromic with elevation of total protein. Computed tomography (CT) showed mixed-density bilateral ventricular masses.
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