[Comparison of its and orientation tuning dynamics in neurons located in different functional domains of cat's primary visual cortex].

Orientation tuning and its dynamics of cat's primary visual cortex neurons located in pinwheel centers and orientation columns were studied during development of response in time. Functional domains in the Cortex were revealed by intrinsic signal optical imaging on functional and vascular maps of cortex. Both maps were used for precise placement of electrodes during recordings.

[Alpha- and beta-oscillations of dynamics of the area and weight of receptive fields of cat striate neurons under conditions of classical and combined mapping].

In 22 acute experiments in anesthetized and immobilized adult cats the dynamics of 83 receptive fields (RF) of 47 striate neurons was studied by temporal slices method. Classical mapping revealed wave-like changes in the area and weight of neuronal RFs. Special mathematical analysis showed that such changes represented a sum of a slow non-oscillatory and comparatively fast components.

Self condensation of enamines mediated by acetylation. A novel approach to 1-(azol-5-yl)-(1E,3Z)-butadiene-4-N,N-dimethylamines.

Novel self-condensation of 3-(azol-5-yl)-1,1-dimethylenamines has been found to form new C-C bonds leading to 2,4-(1,2,3-triazole-1,2,3-thiadiazole-3-phenylisothiazole)-(1E,3Z)-5-yl-butadiene-1-amines. The discovered reaction represents a new example of C-H functionalization in unsaturated systems and can serve an efficient synthetic approach to rational design of new 2,4-(diazole-5-yl)-dieneamines.

[Receptive fields of cat striate neurons: dynamics of weight and topographical characteristics of the excitatory zone of the neuron receptive fields in the visual cortex].

In 22 acute experiments on anesthetized and immobilized adult cats, the dynamics of 83 on- and/or off-receptive fields (RF) was studied in 47 striate neurons with the method of temporal slices by mapping with single-flash stimuli. The latency of the RF appearance was 88 +/- 5 ms, and its duration was 192 +/- 12 ms. Dynamical wavy changes in the RF sizes and weights repeating up to three times were revealed.

[Receptive fields of detectors of bar and cross-like figures in classical and combined mapping].

Excitatory and inhibitory zones of receptive fields (RF) of detectors of cross-like figures and bars were studied in a primary visual cortex of cats under conditions of classical and combined mapping. Factor and correlation analysis demonstrated that detectors of bars and crosses differ in those interrelations, which are formed between the basic characteristics of neurons and their RF in each of group. The factor analysis of these connections showed that variables with the greatest weights, combined into the same factor, are different for different detectors.

[Striate receptive fields mapped with single and bipartite stimuli].

In 22 acute experiments with anesthetized and immobilized adult cats, 364 maps of receptive fields (RF) of 47 striate neurons were obtained by means of single local stimuli flashed at different parts of the visual field, or with additional asynchronous activation of the RF excitatory center with oscillating bar of the optimal orientation. Under bipartite stimulation, considerable and significant decrease in the square and weight of the central excitatory RF zone was revealed in more then 75% of the studied cells. Additional excitatory zones appeared in 54% of cases, or the square and weight of the excitatory zones substantially increased, and inhibitory zones developed in 90% of cases.

Neurophysiological and simulation studies of striate cortex receptive field maps: the role of intracortical interneuronal interactions.

Acute experiments on 27 adult anesthetized and immobilized cats investigated 101 on and off receptive fields in 67 neurons in visual cortex field 17 by mapping using single local stimuli presented sequentially at different parts of the visual field, as well as in combination with additional stimulation of the center of the receptive field. Both classical and combined mapping identified receptive fields with single receptive zones (63.4% and 29.

[Neurophysiological and simulation study of the striate receptive fields maps: the role of intracortical interaction].

In 27 acute experiments with anesthetized and immobilized adult cats 101 maps of receptive field (RF) in 67 striate neurons were studied by means of mapping with single flashed stimuli presented in different parts of the visual field and under conditions of additional activation of the RF excitatory center by the local oscillating or flashing grid. Under conditions of both classical and combined modes of mapping, the RFs of the classical shape with a single excitatory zone (63.4 and 29.

The time course of disinhibition of visual cortex neurons and sensitivity to cross-shaped figures.

The relationship between the responses of 74 neurons in field 17 of the cat cortex to presentation of cross-shaped figures flashing in their receptive fields and the asynchronicity with which the lines of the figures were presented were investigated. The cross sensitivity of neurons was studied with simultaneous, leading, and delayed activation of the disinhibitory zone of the receptive field in relation to the time at which its major excitatory and end-stopping inhibitory zones were stimulated. Two types of temporal interaction were identified between the receptive field zones determining cross sensitivity.

Dynamic changes in the tuning of striate neurons to the shapes of cross-shaped figures.

Time slice analysis was used to study the dynamics of tuning to the shapes of cross-shaped figures flashing in the receptive fields of 83 neurons in the primary visual cortex (field 17) of the cat brain. Tuning was assessed in terms of the numbers of spikes in the overall response and its sequential 20-msec fragments. Only 11.

[Temporal course of disinhibition of the visual cortex neurons and their sensitivity to cross-like figures].

In acute experiments with narcotized and paralyzed cats, we studied responses of 74 striate neurons to cross-like figure under synchronous and asynchronous presentation of its lines. The aim of the study was to characterize the temporal course of interaction between three RF zones: main excitatory, end-inhibitory, and side disinhibitory ones. Previously we have found that this interaction is responsible for sensitivity to a cross in near 3/4 of cat striate cells with such sensitivity.

[Dynamics of tuning to orientation of cross-like figures in neurons from the cat visual cortex].

Dynamics of tuning to orientation of flashing light bar and to orientation of cross-like figure was studied by a temporal slices method in 87 neurons of the cat primary visual cortex. Tuning was plotted by spikes number in the entire response and in its successive fragments with a step of 20 ms. It was found that successive dynamic shift of preferred orientation of a bar was typical for 87% units, white such shift of preferred orientation of a cross was met in 75% of cases.

[Dynamics of tuning to the shape of a cross-like figure in striate neurons].

Dynamics of tuning to the shape of cross-like figure flashed in receptive field was studied in 83 striate neurons by the method of temporal slices. Tuning was estimated by the total number of spikes in the response and by this number in successive fragments of the response with 20 ms steps. It was found that only in 11.

[Optimization of anesthesiological management of reoperations in patients with renal transplant].

Tasks of anesthesiology support of reoperations in patients with renal allografts are determined; a classification of reoperations is offered. Vital functions in patients subjected to reoperations are evaluated. A method of anesthesia for various types of reoperations is suggested.

The disinhibitory zone of the striate neuron receptive field and its sensitivity to cross-like figures.

Acute experiments on immobilized anesthetized cats were used to confirm the suggestion that the sensitivity of many neurons on the primary visual cortex to cross-shaped, angular, and Y-shaped figures may be determined by the presence within their receptive fields of disinhibitory zones, which block end-stopping inhibition. A total of 55 neurons (84 functions, i.e.

[Disinhibitory zone of the striate neuron receptive field and its sensitivity to the cross-like shape].

Sensitivity of 84 neurones to presentation of cross-form figures was studied in cats as well as the lever length function prior to and after stimulation of the RF disinhibitory zone. Responses to lever length of the cross-sensitive cells were augmented in simultaneous stimulation of the RF. The data obtained suggest involvement of the end inhibition and its blocking by a side-disinhibitory zone of the RF.

Tuning to Y-like figures in the cat striate neurons.

Sensitivity to symmetric or asymmetric Y-like figures and crosses of different shapes and orientations flashed in the receptive field was studied in 101 neurons of the cat striate cortex (area 17) and compared with their orientation tuning to a single light bar. Selective sensitivity to the Y-like figure (figure/bar response ratio more than 1.25) was found in 78/101 neurons (77.

Interrelation of tuning characteristics to bar, cross and corner in striate neurons.

Characteristics of responses and background activity, as well as of tuning to a single bar orientation and to cross or corner shape and orientation have been compared in one third (561174) of neurons in the cat striate cortex. Shortening of the response latency to cross vs bar, to corner vs bar and to corner vs cross was revealed in most of the units studied. Direct correlation between the response and tuning characteristics for bar, cross and corner was revealed: units with better tuning to one type of stimulus were typically better tuned to the other types of stimuli.

[The sensitivity of the cat visual cortex neurons to cruciform figures during stimulation of the central and peripheral receptive fields].

The role of the central and peripheral zones of the receptive field (RF) in sensitivity to cruciform figures was studied in 29 neurons of the cat primary visual cortex. Separated or combined stimulation of these zones revealed summation, reciprocity response interaction, or the absence of their interaction by the sensitivity index (ratio between response magnitudes to a cruciform figure and a bar). Stimulation of only central or only peripheral zone of the RF in nearly equal number of cases increased or decreased the sensitivity index in comparison with full cruciform figure.

Selective and invariant sensitivity to crosses and corners in cat striate neurons.

Many neurons (56/174, or 32.2%) studied in the cat striate cortex (area 17) increased significantly (by 3.3 times on average) their responses under stimulation by cruciform or corner figures of specific or non-specific shape and orientation flashing in receptive field as compared with single light bar of preferred orientation.

[The characteristics of the neurophysiological diagnosis and the main directions in the differentiated therapy of brain edema and swelling in patients who are in a critical state].

A total of 186 patients with encephalopathies caused by critical states and reanimation were examined. A complex of neurophysiologic studies was proposed involving impedancemetry of the brain, rheoencephalography, echoencephalography, electroencephalography, ophthalmoscopy. The studies made showed that adoption of the proposed complex permits differentiating the processes of edema, swelling, edema-swelling of the brain as well as determining the condition of cerebral bloodflow and assessing the extent of impairement of cerebral homeostasis.

Sensitivity to cross-like figures in the cat striate neurons.

The responses and orientation tuning in 48 out of 62 (77.4%) neurons of the cat striate cortex (area 17) significantly, but with different sign, changed at stimulation by specific cross-like figure flashing in receptive field as compared with single light bar of preferred orientation. Neurons of the first group (19 units from 62, 30.

Dynamics of orientation tuning in the cat striate cortex neurons.

Dynamics of orientation tuning was studied by a flashing light bar in 233 single units of cat primary visual cortex. Orientation tuning was plotted by the criterion of spike number in successive fragments of responses with a step of 10 or 20 ms. Preferred orientation and the width of orientation tuning were measured for each of such curves.

[A clinical and morphological study of status asthmaticus].

Clinical and morphologic studies were carried out in 230 patients suffering a grave course of an exacerbation of infectious bronchial asthma. A protracted attack of the condition was detected in 70 patients, in 80 patients status asthmaticus, Stages I-II was found, 50 patients suffered a Stage III status asthmaticus, and 30 patients were hospitalized in the terminal state and died within 12 hours since admission. The circulatory, metabolic, immunologic homeostasis parameters were studied, morphologic, examination of pulmonary, tracheal, cardiac, cerebral, splenic and hepatic tissue was carried out in 30 patients who died at the height of the status asthmaticus.

[Liposomes in the combined treatment of patients with chronic obstructive bronchitis].

Liposome inhalation was included into intensive combined treatment of 78 patients with chronic bronchitis exacerbation and preasthma. As shown by investigations of respiration, central hemodynamics, lipid and protein metabolism, vitamin E concentration, chemiluminescence before, during and after treatment, liposomes promote elimination of obstruction in the airways, pO2 normalization, correction of impaired lipid and protein metabolism, an increase in vitamin E level in peripheral blood leading to antioxidant system recovery and inhibition of lipid peroxidation. The use of lipin reduces the time of treatment of bronchitis chronics 2-fold.