Publications by authors named "Novi Irmania"
In this work, manganese (Mn)-doped CuInSe quantum dots (QDs) with a ZnS passivation layer (MnCuInSe/ZnS) have been synthesized via a one-pot microwave-assisted hydrothermal reaction using glutathione (GSH) as a stabilizer. The MnCuInSe/ZnS core-shell QDs combine magnetic resonance imaging (MRI), excitation-dependent red emission, and reactive oxygen radical generation functions, in which regulation of Mn incorporation leads to synergistic imaging and therapeutic modalities. The MnCuInSe/ZnS QDs exhibit high colloidal and photochemical stability in simulated media and at different pH values.
View Article and Find Full Text PDFManganese-doped green tea-derived carbon quantum dots as a targeted dual imaging and photodynamic therapy platform.
J Biomed Mater Res B Appl Biomater
May 2020
Article Synopsis
- Manganese-doped carbon quantum dots (Mn-CQDs) were synthesized from waste green tea using a hydrothermal method, enhancing their magnetic resonance properties and water solubility.
- The Mn-CQDs were functionalized with amine groups and conjugated to folic acid and chlorin e6 to create a targeted photodynamic therapy (PDT) agent effective against HeLa cancer cells.
- In vitro studies showed that the Mn-CQDs@FA/Ce6 combination provided enhanced MRI signals and killed over 90% of cancer cells with light irradiation, demonstrating its potential as a dual-modal imaging and therapy tool.