Publications by authors named "Novel Njweipi Chegou"
Article Synopsis
- The study explored the effectiveness of blood-based transcriptomic signatures in diagnosing tuberculosis (TB) compared to other respiratory infections in patients hospitalized in a low-TB endemic country.
- Researchers analyzed the expression of 26 specific genes using qPCR on blood samples from 31 patients, finding a significant age difference between TB and non-TB cases and identifying a three-gene signature for TB diagnosis.
- The three-gene signature showed promising diagnostic accuracy with an AUC of 0.86, indicating good potential for future TB diagnosis, though the impact of factors like age on results needs to be investigated further in larger studies.
Cytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary disease.
BMC Immunol
October 2020
Background: Previous studies have shown that tuberculosis (TB) is a risk factor for chronic airflow limitation. Chronic obstructive pulmonary disease (COPD) is recognized as the result of chronic inflammation, usually related to noxious particles. Post-TB airflow obstruction and tobacco-related COPD have the same functional pathway characterized by persistent airflow limitation.
View Article and Find Full Text PDFObjective: The inflammatory profile of chronic obstructive pulmonary disease (COPD) related to tobacco is known in certain studies while that of the post tuberculosis form is not yet known. This study aimed to evaluate the levels of neutrophils, macrophages and lymphocytes cells in sputum of COPD patients with history of smoking or anterior tuberculosis. Enumeration of cells in samples was analyzed using standard microscopy.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess the use and acceptance of new rapid tuberculosis (TB) diagnostic tests among global TB experts, aligning with World Health Organization standards.
- An online survey conducted from July to November 2016 received responses from 723 individuals across 114 countries, revealing that smear microscopy was the most common test used, while molecular assays were also widely utilized, especially in poorer countries.
- Despite the current availability of tests, experts expressed a strong willingness to adopt novel rapid tests, particularly molecular and serological assays, emphasizing the need for further training and education in their application.