Patients undergoing cardiac surgery are at high risk of postoperative bleeding, which is related to worse prognosis and survival. The use of ROTEM®, together with the implementation of a specific treatment algorithm, to reduce the risk of postoperative bleeding. An observational, comparative, cross-case study with historical controls.
View Article and Find Full Text PDFJ Allied Health
January 2019
Learning management systems (LMSs) are available to faculty in many higher education institutions; however, not all faculty members take advantage of the tools LMSs offer in facilitating their face-to-face classes. To deepen understanding of this gap, this study explored faculty's experiences in LMS usage and factors that affected faculty's use of LMS to facilitate classroom learning. For this qualitative study, data were collected through interviews with various allied health faculty (n=10), and content analysis was used to identify themes.
View Article and Find Full Text PDFWe present a patient with panfacial neurofibromatosis type 1 who underwent allogeneic transplantation of facial structures, which was complicated by severe rhabdomyolysis and temporary oligoanuria. Because of his underlying disease, this 35 year-old man, weighing 68 kg and with a body mass index (BMI) of 27, had undergone 17 operations for resection modeling of hypertrophied tissues, either alone or combined with static suspension techniques. He finally underwent allogeneic transplantation of facial structures.
View Article and Find Full Text PDFBackground/aims: The survival of patients with colorectal cancer has not varied appreciably in recent years. The knowledge that genetic factors and disruption in apoptosis could play a role in the etiology and prognosis of patients with sporadic colorectal cancer has opened up new lines of research. We have studied a group of patients with colorectal cancer and the possible influence on the prognosis of immunohistochemical MSH2, M30 cytodeath and cytokeratin 20 expression.
View Article and Find Full Text PDFAlthough the pathophysiological mechanisms leading to endometriosis remain unknown, several hypothesis have been proposed, including a dysregulation of the normal apoptotic process which takes place in the endometrium. One of the apoptotic pathways playing a crucial role in the programmed cell death within the endometrium is the Fas-FasL system. In this study we have performed a case-control analysis in order to evaluate three polymorphisms located within FAS (-1377G>A and -670A>G) and FASL (-843C>T) genes, as susceptibility factors for endometriosis.
View Article and Find Full Text PDFInt J Biol Markers
February 2005
Introduction And Aims: The role of genetic factors in the etiology and prognosis of patients with sporadic colorectal cancer is controversial. We have therefore investigated the biological and clinicopathological influence of immunohistochemical MSH2 expression in colorectal cancer.
Patients And Methods: A total of 49 consecutive patients with unselected colorectal cancer operated on in our unit were included in the study.
Int J Biol Markers
January 2004
Introduction And Aims: The role of genetic factors in the etiology and prognosis of patients with sporadic colo-rectal cancer is controversial. We have therefore investigated the biological and clinicopathological influence of immunohistochemical MSH2 expression in colorectal cancer.
Patients And Methods: A total of 49 consecutive patients with unselected colorectal cancer operated on in our unit were included in the study.
Several arguments support the proposal that the cytokine network plays a critical role in the aetiology of endometriosis. Among various chemokines, regulated-on-activation, normal-T-cell-expressed and -secreted (RANTES) and monocyte chemotactic protein 1 (MCP-1) concentrations have been shown to be increased in the peritoneal fluid of women with endometriosis. Some studies have demonstrated that, in the context of endometriosis, these chemokines are involved in apoptosis, angiogenesis and/or chemotaxis.
View Article and Find Full Text PDFThe subventricular zone of the rodent brain retains the capacity of generating new neurons in adulthood. The newly formed neuroblasts migrate rostrally toward the olfactory bulb, where they differentiate as granular and periglomerular interneurons. The reported presence of differentiated neurons expressing the neuronal isoform of nitric oxide synthase (NOS) in the periphery of the neurogenic region and the organization of their varicose axons as a network in which the precursors are immersed raised the hypothesis that endogenous nitric oxide (NO) may participate in the control of neurogenesis in the subventricular zone.
View Article and Find Full Text PDFThe RANTES (regulated upon activation normal T cells expressed and secreted) chemokine, is known to be expressed in endometriotic lesions in a concentration correlating with the severity of endometriosis. Since it has been widely demonstrated that endometriosis has a genetic basis, we postulated that the gene encoding RANTES could be a good candidate gene for the disease. We have used fluorescence resonance energy transfer (FRET) technology to genotype and evaluate the role of the variants -403G-->A and -28C-->G, located within the promoter region of the gene, as susceptibility factors in a cohort of Spanish women with endometriosis.
View Article and Find Full Text PDFBackground: Studies on the susceptability of Cryptococcus species to antifungal agents are scarce.
Method: We investigate the susceptibility of 54 clinical and environmental strains from six different species using the Sensititre and the NCCLS methods.
Results: Environmental strains were less susceptible than clinical strains.
The subventricular zone (SVZ) of the adult mouse brain retains the capacity to generate new neurons from stem cells. The neuronal precursors migrate tangentially along the rostral migratory stream (RMS) towards the olfactory bulb, where they differentiate as periglomerular and granular interneurons. In this study, we have investigated whether nitric oxide (NO), a signaling molecule in the nervous system with a role in embryonic neurogenesis, may be produced in the proximity of the progenitor cells in the adult brain, as a prerequisite to proposing a functional role for NO in adult neurogenesis.
View Article and Find Full Text PDFEnferm Infecc Microbiol Clin
February 1999
Enferm Infecc Microbiol Clin
May 1995
Long-term survival of allogeneic vascularized fetal adrenal transplants has been demonstrated in adrenalectomized rats. Significant less mortality occurred after adrenalectomy in animals receiving multiple allogeneic fetal transplants compared to nontransplanted rats.
View Article and Find Full Text PDFLiver homogenates or extracts of liver homogenates from rats in which portacaval shunt had been performed were found to have a significant growth-promoting effect on 7,12 dimethyl (a) benzanthracene (DMBA)-produced breast carcinoma in rats. Tumor potentiation was manifested by increased incidence of animals developing tumors, increased number of tumors, and increased tumor size, when compared with animals receiving injections of shunted or control liver. These observations suggest the existence of a tumor-stimulating factor in liver from which portal blood has been completely and chronically diverted by portacaval shunt.
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