[Good laboratory practice of equilibrium solubility measurement II. Study of pH-dependent solubility of ionizable compounds].

In this paper the pH-equilibrium solubility profiles of ionizable drugs are presented. The aim of the present work was to study the validity of the Henderson-Hasselbalch (HH) relationship in the case of structurally diverse weak bases. In the case of monoprotic bases, namely papaverine, promethazine and propafenone the experimental equilibrium solubility data precisely follow the theoretical HH curve until the limit of salt solubility.

[Current problems in the quality control of pharmaceutical preparations manufactured in pharmacies III. Investigation of theophilline containing suppositories].

In the present part of our series of papers a study on theophilline containing suppositories prepared in pharmacies is described. From the possible methods for assay of theophilline two nonaqueous titrations are compared. In first, theophilline is measured as a very weak base in a mixture of glacial acetic acid and acetic anhydride with perchloric acid using Sudan-III indicator, in second, the compound is measured as medium strong acid in dimethylformamide solvent with sodium-hydroxide titrant using phenolphtalein indicator.

[Current problems in the quality control of pharmaceutical preparations manufactured in pharmacies II. Paracetamol contraining preparations].

In our previous paper identification methods using chemical reactions and TLC are described for the active ingredients of pharmaceutical preparations in Formula Normales (FoNo VII.). Present paper introduces the development and validation of analytical methods suitable for quantitative determination of paracetamol containing dosage forms in FoNo VII.

[Pharmaceutical chemistry of major analgesics].

The paper represents the 5th part of a series about agents acting on the central nervous system. This time the major analgesics are surveyed. As previously, the material is divided into chapters of hystory-preparation; structure-properties-activity; therapeutical use; analysis.

[Pharmaceutical chemistry of general anaesthetics].

The paper represents the first part of a planned series of reviews about pharmaceutical chemistry of drugs acting on the central nervous system. The authorial aim and editorial concepts are the same were followed in a former series of papers about pharmaceutical chemistry of agents effecting the heart, blood circulation and vegetative nervous system. Consequently, general anaesthetics are discussed in the present paper through the chapters "history, preparation; structure-properties-activity; application; analysis".

[Pharmaceutical chemistry of sedato-hypnotics and anxiolytics].

The paper represents the 2nd part of a series about agents acting on the central nervous system. As previously, the material is divided into chapters of hystory, preparation; structure-properties-activity; therapeutical use; analysis.

[Measure of alkalinity in an alcohol/water mixture by potentiometric end-point detection. Critical remarks on a new method in the European pharmacopoeia].

The European Pharmacopoeia introduced a new alkalimetric method for assay of alkaloid (and other N-base) salts. The principle of method is: after preliminary addition of small amount of hydrochloric acid, titration is carried out with 0.1 N NaOH in alcohol/water mixture with potentiometric end-point detection.

[EFfect of quinazolone-alkyl-carboxylic acid derivatives on the transmembrane Ca2+ ion flux mediated by AMPA receptors].

The excitatory neurotransmitter, Glu, plays a crucial role in many sensory and motor functions as well as in brain development, learning and memory and it is also involved in the pathogenesis of a number of neurological disorders, including epilepsy, Alzheimer's and Parkinson's diseases. Therefore, the study of Glu receptors (GluRs) is of therapeutical importance. We showed here by fluorescence monitoring of transmembrane Ca2+ ion fluxes in response to (S)-alpha-amino-3-hidroxi-5-metil-4-izoxazol propionic acid ((S)-AMPA) on the time scale of 0.