A comparative evaluation of subendometrial and intrauterine platelet-rich plasma treatment for women with recurrent implantation failure.

Objective: To compare the effectiveness of treatment with autologous activated platelet-rich plasma (PRP), administered to either the subendometrium (SE-PRP) or endometrial surface (intrauterine; IU-PRP), against controls.

Design: Prospective observational cohort study.

Setting: Tertiary fertility unit.

Dehydroepiandrosterone (DHEA) role in enhancement and maintenance of implantation (DREAM): randomised double-blind placebo-controlled trial-study protocol.

Introduction: Dehydroepiandrosterone (DHEA) is an important precursor of androgen and has been studied and researched extensively for improving the various outcome measures of ovarian stimulation in women with advanced age or poor ovarian response. Androgens also play an important role in the enhancement of endometrial and decidual function by regulating both the transcriptome and secretome of the endometrial stromal cells and have a positive effect on various factors like insulin-like growth factor binding protein 1, homeobox genes (HOXA10, HOXA11), secreted phosphoprotein 1, prolactin which are necessary for implantation. It is well-known that the circulating 'precursor pool' of DHEA declines with age more so in poor ovarian reserve patients and exogenous supplementation may be beneficial in such cases.

Epidemiology of cutaneous leishmaniasis in Afghanistan. Part I: Zoonotic cutaneous leishmaniasis.

From June to September 1977, a preliminary epidemiological investigation was carried out in some parts of northern Afghanistan (Aqcha, Mazar-e-Sharif and Paul-e-Khombri). The disease in these areas is of zoonotic type having Rhombomys opimus as reservoir and P. caucasicus and P.