cytotoxicity screening of some 3-substituted-4-oxo-imidazolidin-2-(1H)-thione derivatives as anticancer drug.

This study aimed to investigate the antitumor activity of new series of 2-thiohydanotin derivatives ( and ) against two cancer cell lines. A new series of 2-thioxoimidazolidine derivatives () were synthesized and investigated for its structure through spectral analysis and also tested against (HepG-2) and (HCT-116) cell line. Among the synthesized compounds, compound halted liver cancer cells at the G0/G1 phase and triggered apoptosis of liver cancer.

anti-breast cancer study of hybrid cinnamic acid derivatives bearing 2-thiohydantoin moiety.

: To synthesize new hybrid cinnamic acids (, and ) and ester derivatives (, and ) and investigate their anti-breast cancer activities. Compounds were evaluated () for their cytotoxic activities against the MCF-7 cell line. A flow cytometry examination was performed.