Novel sulfonamide derivatives as multitarget antidiabetic agents: design, synthesis, and biological evaluation.

A series of new sulfonamide derivatives connected through an imine linker to five or seven membered heterocycles were designed and synthesized. All synthesized derivatives were characterized using a variety of spectroscopic methods, including IR, HNMR, and CNMR. α-glucosidase and α-amylase inhibition activities, as well as glucose uptake were assessed for each of the synthesized compounds.