Adropin/Tirzepatide Combination Mitigates Cardiac Metabolic Aberrations in a Rat Model of Polycystic Ovarian Syndrome, Implicating the Role of the AKT/GSK3β/NF-κB/NLRP3 Pathway.

Polycystic ovarian syndrome (PCOS) is a multifaceted metabolic and hormonal disorder in females of reproductive age, frequently associated with cardiac disturbances. This research aimed to explore the protective potential of adropin and/or tirzepatide (Tirze) on cardiometabolic aberrations in the letrozole-induced PCOS model. Female Wistar non-pregnant rats were allotted into five groups: CON; PCOS; PCOS + adropin; PCOS + Tirze; and PCOS + adropin+ Tirze.

Predictors for prolonged qt intervals in acute antipsychotic poisoned patients.

Background: Acute antipsychotic poisoning is correlated to a high prevalence of qt interval prolongation.

Aim: This study aimed to evaluate early qt interval prolongation predictors in acute antipsychotic-poisoned patients.

Methodology: This prospective cohort study enrolled 70 symptomatic patients with acute antipsychotic poisoning.