Publications by authors named "Noura Tbeileh"
Article Synopsis
- Advanced colorectal adenocarcinoma (CRC) with high stroma levels indicates poorer prognosis and complicates the detection of genetic mutations in tumors.
- This study used whole exome sequencing (WES) on a collection of CRC liver metastasis samples to assess stroma-cancer cell interactions, showing a median tumor purity of only 30% in metastatic specimens compared to 94% in cancer cell-rich organoids.
- Three computational tools, ABSOLUTE, Sequenza, and PureCN, were tested for estimating tumor purity, revealing varied results, with Sequenza and PureCN providing consistent findings while ABSOLUTE reported lower purity levels; this highlights the importance of unbiased sample selection and diverse assessment methods in cancer research.
Motivation: Clustered mutations are found in the human germline as well as in the genomes of cancer and normal somatic cells. Clustered events can be imprinted by a multitude of mutational processes, and they have been implicated in both cancer evolution and development disorders. Existing tools for identifying clustered mutations have been optimized for a particular subtype of clustered event and, in most cases, relied on a predefined inter-mutational distance (IMD) cutoff combined with a piecewise linear regression analysis.
View Article and Find Full Text PDF