Upregulation of Twist2 in Non-Muscle Invasive Urothelial Carcinoma of the Bladder Correlate with Response to Treatment and Progression.

Background: Twist2 is a transcription factor and an epithelial-to-mesenchymal transition that plays an important role in cell polarity, cell adhesion, and has a role in tumour invasion and metastases.

Aim: In this study, we examined the expression of Twist2 in non-muscle invasive bladder carcinoma (NMIBC) and correlated the expression with response to treatment and tumour progression.

Methods: Data of 305 patients with NMIBC of Ta, T1 were retrieved from hospitals archives.

TWIST2 EXPRESSIONS IN PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THE URINARY BLADDER SHOWED DOWN REGULATION CORRELATED WITH GOOD SURVIVAL AND LOW INCIDENCE OF DISTANT METASTASIS.

This study evaluated the association between expression of Twist2 monogenic, with pathological features and clinical outcomes of squamous cell carcinoma of the urinary bladder (SCCUB) following radical cystectomy (RC). Immunohistochemical staining Twist2 was performed on tissue archival samples comprising normal urothelium from ten controls, cystectomy specimens from 87, patients with T2 NO MO and T3-4a NO MO of bladder squamous cell carcinoma (SCC).all patients with T2-4 SCC undergone radical cystectomy and urinary diversion, follow up was for 5-10 years to assess overall survival (OS) and disease free survival (DFS).