Prompt diagnosis of preeclampsia is key to ensure appropriate management and reduce associated adverse outcomes. Placental growth factor (PlGF)-based biomarkers have been shown to be safe and effective diagnostic tools for preterm preeclampsia, and their use is recommended by most recent Canadian guidelines. The present report summarizes an expert panel discussion that led to the development of a proposed utilization algorithm for PlGF-based diagnostic testing for suspected preeclampsia in Québec.
View Article and Find Full Text PDFGlibenclamide is one of the most prescribed insulin secretagogues in diabetes due to its low cost, but its efficacy on suppressing diabetic complications is limited. Here, we examine whether addition of either vitamin B1 or calcitriol to glibenclamide could produce more suppression of diabetic nephropathy. Type 2 diabetes was induced by high fructose (10 % in drinking water), high salt (3 % in diet), and high fat diet (25 % in diet) for 3 weeks, followed by single dose of STZ (40 mg/kg, i.
View Article and Find Full Text PDFThe Paris Agreement, a landmark international treaty signed in 2016 to limit global warming to 2°C, has urged researchers to explore various strategies for achieving its ambitious goals. While Renewable Energy (RE) innovation holds promise, it alone may not be sufficient as critical deadlines approach. This field of research presents numerous challenges, foremost among them being the costliness of materials involved.
View Article and Find Full Text PDFBackground: Pomegranate granatum (molasses and peels) and its constituents showed protective effects against natural toxins such as phenylhydrazine (PHZ) as well as chemical toxicants such as arsenic, diazinon, and carbon tetrachloride.
Aim: The current study aimed to assess the effect of pomegranate molasses (PM), white peel extract, and red peel extract on nephrotoxicity induced by PHZ.
Methods: 80 male rats were divided into eight equal groups; a control group, PM pure group, white peel pomegranate pure group, red peel pomegranate pure group, PHZ group, PM + PHZ group, white peel pomegranate + PHZ group and red peel pomegranate + PHZ group.
Objectives: To (1) define quality indicators, (2) describe care gaps, and (3) identify process issues in severe hypertension (sustained systolic blood pressure [BP] ≥160 mm Hg or diastolic BP ≥110 mm Hg) management at our tertiary care centre.
Methods: Pregnant and postpartum persons diagnosed with a hypertensive disorder of pregnancy from 2018 to 2019 were identified. A retrospective cohort of patients with severe hypertension was constructed, and data were collected through chart review.
Naunyn Schmiedebergs Arch Pharmacol
June 2023
Hinokitiol, a natural monoterpenoid, has been shown previously to possess a potent vasodilating activity in vitro in both control and hypertensive aortae. Here, the antihypertensive and cardioprotective effects of an intravenous hinokitiol injection were fully investigated in angiotensin II-induced hypertensive emergency in rats. Hinokitiol intravenous injection was prepared in the form of self-nanoemulsifying drug delivery system.
View Article and Find Full Text PDFHinokitiol is a natural bioactive compound with numerous pharmacological properties. Here, we aimed to examine hinokitiol's effects on vascular relaxation. Cumulative relaxation responses to hinokitiol were assessed in isolated aortae from normotensive and angiotensin II-induced hypertensive rats in the presence and absence of selective inhibitors.
View Article and Find Full Text PDFMetabolic syndrome (MetS) is closely associated with the development of cardiovascular diseases. We recently developed a nano-preparation of the flavonoid quercetin (QU) in a self-nanoemulsifying drug delivery system (SNEDDS). The latter comprised a mixture composed of pumpkin seed oil, D-α-Tocopherol polyethylene glycol 1,000 succinate and polyethylene glycol.
View Article and Find Full Text PDFVasodilators are an important class of antihypertensive agents. However, they have limited clinical use due to the reflex tachycardia associated with their use which masks most of its antihypertensive effect and raises cardiac risk. Chemical investigation of afforded five major methoxylated flavonoids () three of which (, , and ) showed vasodilator activity.
View Article and Find Full Text PDFThe recent digital revolution led robots to become integrated more than ever into different domains such as agricultural, medical, industrial, military, police (law enforcement), and logistics. Robots are devoted to serve, facilitate, and enhance the human life. However, many incidents have been occurring, leading to serious injuries and devastating impacts such as the unnecessary loss of human lives.
View Article and Find Full Text PDFInternet Things (Amst)
September 2020
Recently, the world witnessed a significant increase in the number of used drones, with a global and continuous rise in the demand for their multi-purpose applications. The pervasive aspect of these drones is due to their ability to answer people's needs. Drones are providing users with a bird's eye that can be activated and used almost anywhere and at any time.
View Article and Find Full Text PDFMicroprocess Microsyst
September 2020
Typically, Cyber-Physical Systems (CPS) involve various interconnected systems, which can monitor and manipulate real objects and processes. They are closely related to Internet of Things (IoT) systems, except that CPS focuses on the interaction between physical, networking and computation processes. Their integration with IoT led to a new CPS aspect, the Internet of Cyber-Physical Things (IoCPT).
View Article and Find Full Text PDFVasodilators are important pharmacologic agents for managing and/or treating hypertension. Medicinal plants are considered as valuable source of bioactive compounds. We used a bioguided approach to isolate, identify, and investigate the possible vasodilation activities and mechanism(s) of the prepared methanol extract from aerial parts of (MAPP), its bioactive fraction and active compounds.
View Article and Find Full Text PDFBackground: Healthcare cost management strategies are limited in number and resource intensive. Budget constraints in the National Health Service Scotland (NHS Scotland) apply pressure on regional health boards to improve efficiency while preserving quality.
Methods: We developed a technical method to assist health systems to reduce operating costs, called continuous value management (CVM).
Background: Hypertension is a serious component of metabolic syndrome (MetS).
Hypothesis: This research investigates the potential protective effect of limonin against MetS-associated hypertension in comparison with azelnidipine, a common calcium channel blocker.
Study Design: MetS was induced in rats by 10% fructose in water and 3% salt in diet over a 16-week period.
Rift Valley Fever (RVF) is a mosquito-borne zoonosis, which may cause significant losses for the livestock sector and have serious public health implications. Egypt has been repeatedly affected by RVF epidemics, mainly associated to the importation of animals from sub-Saharan countries, where the disease is endemic. The objective of our study was the improvement of the surveillance and control strategies implemented in Egypt.
View Article and Find Full Text PDFBackground: To evaluate the hazard of prolonged antibiotic therapy and/or persistent diarrhea on vitamin K1 (VK1) level and bleeding profile in infants (2-24 weeks).
Methods: A one-year case-control study, conducted at Ain Shams University, Egypt. 338 infants (2-24 weeks) were recruited and divided into 3 groups (1:1:3 ratios); group A (n=67) patients who received antibiotics for ≥10 days, group B (n=67) who had persistent diarrhea ≥ 14 days and group C (n=204) age- and gender- matched infants who had not either received antibiotics nor had diarrhea.
Background: The aim of this study was to elucidate the impact of both pre and postprocessing total motile sperm count (TMSC) on pregnancy rates in a subfertile population undergoing intrauterine insemination (IUI).
Methods: Subfertile couples presenting to the Stanford University Fertility Center during a two-year period were retrospectively enrolled. Eligible couples consisted of women with good ovarian reserve, proven tubal patency, normal anatomy and inducible ovulation.
The present work investigated the possible protective effect of baicalein, a natural lipoxygenase enzyme inhibitor, on both insulin deficiency (ID) and insulin resistance (IR)-induced macro-vascular impairment. ID and IR were induced by STZ or fructose for 8 or 12 weeks respectively while baicalein was administered in the last six weeks. Blood pressure (BP) was recorded and isolated aorta reactivity to phenylephrine (PE) and acetylcholine (ACh) were studied.
View Article and Find Full Text PDFObjective: Marfan syndrome (MFS) is a rare connective tissue disease with significant risk for adverse cardiovascular outcomes. Our objective was to evaluate pregnancy and cardiovascular outcomes in pregnant women with MFS.
Study Design: We conducted a population-based retrospective cohort study using the Healthcare Cost and Utilization Project Nationwide Inpatient Sample (HCUP NIS) database from 2003 to 2010.
Atherosclerosis is a major macrovascular complication of diabetes that increases the risks for myocardial infarction, stroke, and other vascular diseases. The effect of a selective 5-lipoxygenase enzyme inhibitor; caffeic acid phenethyl ester (CAPE) on diabetes-induced atherosclerotic manifestations was investigated. Insulin deficiency or resistance was induced by STZ or fructose respectively.
View Article and Find Full Text PDFVascular complications are the leading cause of morbidity and mortality in patients with diabetes. Quercetin is an important flavonoid with antioxidant and anti-inflammatory activity. Here, the effect of quercetin on diabetes-induced exaggerated vasoconstriction in insulin deficient and insulin resistant rat models was investigated.
View Article and Find Full Text PDFIntroduction: Inguinal herniotomy in children is still dominated by conventional open inguinal herniotomy (COIH) as laparoscopic techniques have yet to demonstrate clear advantages. A technical modification that minimizes the incision of COIH in selected children can offer another minimally invasive alternative. A comparative analysis of safety, efficacy, and parental attitudes between mini-scar inguinal herniotomy (MSIH) and COIH was performed.
View Article and Find Full Text PDFObjective: To determine the prevalence of restless legs syndrome (RLS) in women with systemic lupus erythematosus (SLE), and to compare this to a rheumatic disease sample without SLE.
Methods: Unselected consecutive female patients were SLE were recruited from a lupus clinic. A RLS questionnaire based on 4 criteria, validated by the International Restless Legs Syndrome Study Group, was administered during a face-to-face interview.