Risks of prostate cancer and mortality in the city of Sharjah, United Arab Emirates.

Background: Prostatic hyperplasia (BPH) and prostate cancer (PCa) are common age-related diseases in men. According to World Health Organization (WHO), PCa is the second most common cancer among Emirati men. This study aimed to identify the risk factors associated with PCa and mortality in a cohort diagnosed with PCa between 2012 and 2021 in Sharjah, United Arab Emirates (UAE).

Immunohistochemical Assessment of TNFAIP3/A20 Expression Correlates With Early Tumorigenesis in Breast Cancer.

Background/aim: Limited data exist on the expression pattern of TNFAIP3/A20, as assayed by immunohistochemistry (IHC), in breast cancer tissues. This study aimed to assess A20 expression pattern in breast cancer.

Materials And Methods: The expression of A20 was analysed using IHC in 50 breast cancer cases retrieved from the Sharjah Breast Cancer Center at the University Hospital Sharjah, United Arab Emirates.

Calponin 3 promotes invasion and drug resistance of colon cancer cells.

Background: Calponin 3 (CNN3) is an actin-binding protein expressed in smooth muscle and non-smooth muscle cells. It is required for cytoskeletal rearrangement and wound healing.

Aim: To dissect the role of CNN3 in carcinogenesis with a focus on colon cancer.

Role of AXL in invasion and drug resistance of colon and breast cancer cells and its association with p53 alterations.

Aim: To characterize AXL receptor tyrosine kinase (AXL) expression in relationship to tumor protein P53 ( gene, p53 protein) and its role in tumor invasion and response to therapy.

Methods: We used 14 cell lines, including 3 isogenic pairs carrying mutant/knockout p53, to gain insight into the relationship between AXL and . These included HCT116, HCT116.