Publications by authors named "Nour Makarem"

Background: While recent guidelines have noted the deleterious effects of poor sleep on cardiovascular health, the upstream impact of cardiac arrest-induced psychological distress on sleep health metrics among families of cardiac arrest survivors remains unknown.

Methods: Sleep health of close family members of consecutive patients with cardiac arrest admitted to an academic center (August 16, 2021-June 28, 2023) was self-reported using the Pittsburgh Sleep Quality Index (PSQI). The baseline PSQI, focused on sleep in the month before cardiac arrest, was administered during hospitalization and repeated 1 month after cardiac arrest alongside the Patient Health Questionnaire-8 (PHQ-8) to assess depression severity.

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Background: The American Heart Association's Life's Essential 8 (LE8) Presidential Advisory deemed psychological health foundational for cardiovascular health (CVH) but did not include it as a CVH metric.

Objectives: The purpose of this study was to evaluate associations of a CVH construct enhanced with a ninth metric for psychological health based on readily administered depression screening with mortality risk in U.S.

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Chrononutrition is a rapidly evolving field of nutritional epidemiology that addresses the complex relationship between temporal eating patterns, circadian rhythms, and metabolic health, but most prior research has focused on the cardiometabolic consequences of time-restricted feeding and intermittent fasting. The purpose of this topical review is to summarize epidemiological evidence from observational and intervention studies regarding the role of chrononutrition metrics related to eating timing and regularity in cardiometabolic health preservation and cardiovascular disease prevention. Observational studies are limited due to the lack of time-stamped diet data in most population-based studies.

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Background: While recent guidelines have noted the deleterious effects of poor sleep on cardiovascular health, the upstream impact of cardiac arrest-induced psychological distress on sleep health metrics among families of cardiac arrest survivors remains unknown.

Methods: Sleep health of close family members of consecutive cardiac arrest patients admitted at an academic center (8/16/2021 - 6/28/2023) was self-reported on the Pittsburgh Sleep Quality Index (PSQI) scale. The baseline PSQI administered during hospitalization was cued to sleep in the month before cardiac arrest.

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Article Synopsis
  • The study investigates the relationship between sleep apnea severity and hypertension in Hispanic/Latino adults, who often experience high rates of uncontrolled blood pressure, leading to cardiovascular disease (CVD).
  • Data was collected from 2,849 participants with hypertension, focusing on their sleep apnea levels and how these correlate with their blood pressure management while on antihypertensive medications.
  • Results indicate that moderate-to-severe sleep apnea is linked to an increased likelihood of resistant hypertension, suggesting that addressing sleep apnea could help improve blood pressure control and reduce CVD risks in this population.
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  • Cardiovascular Disease (CVD) is the top cause of death worldwide, and Jordan, with its unique healthcare system and demographic factors, is identified as an important case study for understanding CVD trends in the Arab region.
  • Using data from the Global Burden of Disease dataset, research showed that between 1990 and 2019, while the overall burden of CVD mortality and prevalence increased in absolute numbers, age-standardized rates for these and disability-adjusted life years (DALYs) actually decreased in Jordan.
  • The main risk factors for CVD in Jordan in 2019 included high systolic blood pressure, obesity, dietary risks, and high LDL cholesterol, revealing significant health challenges that still need to be addressed despite
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Background: Extreme heat events (EHEs), driven by anthropogenic climate change, exacerbate the risk of cardiovascular disease (CVD), although the underlying mechanisms are unclear. Disturbances in sleep health, caused by excessive heat, may be one way EHEs increase the risk of incident or recurrent CVD. Our objective was to systematically review the empirical peer-reviewed literature on the relationship between EHEs, sleep health, and cardiovascular measures and outcomes, and narratively describe methodologies, evidence, and gaps in this area.

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  • Research shows that better rest-activity rhythms (RARs) can lower the risk of cardiovascular disease (CVD) and related health issues like hypertension and obesity.
  • Participants with more consistent and active daily patterns had significantly lower odds of prevalent CVD and obesity.
  • The study highlights the importance of stable sleep-wake routines, with earlier and restful sleep periods linked to better cardiovascular health outcomes.
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  • Hypertensive disorders of pregnancy (HDP) are linked to long-term cardiovascular risks for women, though the reasons are not fully understood.
  • A study involving 5,168 Hispanic/Latina women revealed that 14% had a history of de novo HDP, which was associated with lower left ventricle ejection fraction and higher risks of abnormal cardiac geometry.
  • Findings indicate that previous HDP can lead to measurable cardiac issues in women, with current hypertension only partially explaining these effects.
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Objectives: To evaluate associations between psychosocial factors and sleep characteristics commonly linked to cardiovascular disease risk among racially/ethnically diverse women.

Methods: Women from the AHA Go Red for Women cohort (N = 506, 61% racial/ethnic minority, 37 ± 16years) were assessed using self-reported questionnaires. Logistic regression models were adjusted for age, race, ethnicity, education, and insurance.

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Objectives: This study sought to conduct a systematic review of the literature on the impact of the COVID-19 pandemic on sleep health among Middle Eastern and North African (MENA) populations, understudied geographic regions including with regards to sleep health.

Setting: A systematic literature search of studies published from inception to 27 March 2022 was conducted on multiple databases using developed keywords.

Participants: Studies were included if they (1) investigated one or more aspects/dimensions of sleep health as an outcome (eg, sleep duration, sleep quality, sleep problems); (2) measured the impact of a COVID-19 pandemic-related domain (eg, impact of quarantine, work from home, lifestyle changes); (3) focused on at least one MENA region population; (4) were peer-reviewed; (5) included ≥100 participants; (6) were written in English and (7) had full-text article publicly available.

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Importance: The Mediterranean diet pattern is inversely associated with the leading causes of morbidity and mortality, including metabolic diseases and cardiovascular disease, but there are limited data on its association with adverse pregnancy outcomes (APOs) among US women.

Objective: To evaluate whether concordance to a Mediterranean diet pattern around the time of conception is associated with lower risk of developing any APO and individual APOs.

Design, Setting, And Participants: This prospective, multicenter, cohort study, the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be, enrolled 10 038 women between October 1, 2010, and September 30, 2013, with a final analytic sample of 7798 racially, ethnically, and geographically diverse women with singleton pregnancies who had complete diet data.

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Purpose Of Review: We discuss the relationship between sleep and circadian factors with cardiovascular disease (CVD) risk, including physiologic, behavioral, and psychological mechanisms along this pathway.

Recent Findings: The relationship between short and long sleep duration, as well as insomnia, with CVD risk is well-established. Recent work has highlighted how other sleep factors, such as sleep regularity (i.

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Article Synopsis
  • * Researchers analyzed data from the Multi-Ethnic Study of Atherosclerosis (MESA) Sleep Study, involving 1920 participants, to create new CVH scores that factor in various sleep characteristics linked to cardiovascular disease (CVD).
  • * Findings indicate that higher scores on the revised CVH measures, particularly those that include sleep health, were associated with significantly lower odds of prevalent and incident CVD among older adults, suggesting sleep is an important factor in cardiovascular health.
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Individual sleep dimensions have been linked to cardiovascular disease (CVD) risk and cardiometabolic health (CMH), but sleep health is multifaceted. We investigated associations of a multidimensional sleep health (MDSH) score, enabling the assessment of sleep health gradients, with CVD and CMH. Participants were 4555 adults aged ≥20 years from the 2017-2018 National Health and Nutrition Examination Survey.

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Objectives: To determine the association between individual, network, and structural COVID-19-related stressors and changes in sleep duration and quality among Black cisgender sexual minority men (SMM) and Black transgender women during the COVID-19 peak infectivity rate in Chicago.

Methods: From April 20, 2020 to July 31, 2020, we conducted the N2 COVID Study in Chicago (n = 226). The survey included questions regarding multi-level COVID-19-related stressors (eg, food unavailability, partner violence, housing instability, concern about neighborhood COVID-19), sleep duration, and sleep quality.

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Background: The timing and regularity of eating patterns could play a role in systemic inflammation, as circadian clocks responsible for daily rhythms of inflammatory signaling are entrained by food intake.

Purpose: To evaluate associations of intra-weekly and weekday-weekend differences in eating timing patterns with high-sensitivity C-reactive protein (hsCRP).

Methods: A community-based sample of 103 U.

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Sleep duration, sleep efficiency, and sleep timing have been shown to have potential effects on metabolic functions relevant to circadian rhythms. It is not clear if the impact of sleep patterns on metabolic risk factors is through sociocultural and environmental factors or circadian misalignment. We investigated the associations of sleep patterns, chronotype, and social jet lag with metabolic syndrome among non-shift worker Hispanic/Latino adults.

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Article Synopsis
  • SGM adults face notable disparities in cardiovascular health, yet there's a lack of understanding regarding their diet and food insecurity impacts.
  • Current research on diet and food insecurity among SGM adults is inconsistent and often lacks reliable methods for assessment.
  • More longitudinal studies are needed to clarify how diet and food insecurity might contribute to the cardiovascular health disparities experienced by SGM adults.
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Jordan, a Middle Eastern country, initially responded to an outbreak of COVID-19 cases within its own borders by imposing a 7-week strict lockdown and closure of international and domestic travel. Such measures drastically influenced lifestyle behaviors of the population. This study aimed to investigate the prevalence of physical activity, and its association with mental and sleep health outcomes among Jordanians during a period of COVID-19 induced lockdown.

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  • Childhood trauma, including abuse and neglect, is linked to poorer cardiovascular health in adulthood, but limited studies have explored how these connections work.
  • An analysis of data from 1,251 participants identified depressive symptoms and sleep quality as significant mediators of this relationship, with women reporting higher levels of trauma and better cardiovascular health than men.
  • The study highlights the need for future longitudinal research and suggests that prevention strategies for heart disease should consider the distinct impacts of childhood trauma based on sex.
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Background Sleep variability and social jetlag are associated with adverse cardiometabolic outcomes via circadian disruption. Variable eating patterns also lead to circadian disruption, but associations with cardiometabolic health are unknown. Methods and Results Women (n=115, mean age: 33±12 years) completed a 1-week food record using the Automated Self-Administered 24-Hour Dietary Assessment Tool at baseline and 1 year.

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The human circadian system consists of the master clock in the suprachiasmatic nuclei of the hypothalamus as well as in peripheral molecular clocks located in organs throughout the body. This system plays a major role in the temporal organization of biological and physiological processes, such as body temperature, blood pressure, hormone secretion, gene expression, and immune functions, which all manifest consistent diurnal patterns. Many facets of modern life, such as work schedules, travel, and social activities, can lead to sleep/wake and eating schedules that are misaligned relative to the biological clock.

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Background: Poor sleep and history of weight cycling (HWC) are associated with worse cardiovascular health, yet limited research has evaluated the association between HWC and poor sleep patterns.

Methods: The American Heart Association Go Red for Women Strategically Focused Research Network cohort at Columbia University (n = 506; mean age, 37 ± 15.7 years; 61% racial/ethnic minority) was used to evaluate the cross-sectional associations of HWC and sleep at baseline and the prospective associations of HWC from baseline with sleep at the 1-year visit.

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