Publications by authors named "Nour Balasan"
Article Synopsis
- Early detection of recurrences in gynecological cancers is vital, and circulating tumor DNA (ctDNA) analysis via liquid biopsy shows promise for monitoring disease progression.
- The study assessed the effectiveness of digital Polymerase Chain Reaction (dPCR) in detecting ctDNA in three patients with confirmed cancer relapses post-surgery, using patient-specific mutations identified through whole-exome sequencing.
- Results indicated that dPCR could detect increased ctDNA levels before traditional serum markers like CA125, but also highlighted the challenges of tumor heterogeneity, as one patient did not show ctDNA signals despite clinical signs of relapse.
Among gynecological cancers, endometrial cancer is the most common in developed countries. Extracellular vesicles (EVs) are cell-derived membrane-surrounded vesicles that contain proteins involved in immune response and apoptosis. A deep proteomic approach can help to identify dysregulated extracellular matrix (ECM) proteins in EVs correlated to key pathways for tumor development.
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