Publications by authors named "Nour Aldeli"
Extensive research has been conducted to investigate the toxicological impact of dioxins on mammals, revealing profound effects on the female reproductive system in both humans and animals. Dioxin exposure significantly disrupts the intricate functions of the ovary, a pivotal organ responsible for reproductive and endocrine processes. This disruption manifests as infertility, premature ovarian failure, and disturbances in sex steroid hormone levels.
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- 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most toxic type of dioxin and has been shown to negatively impact female reproduction.
- The study investigates both acute reproductive toxicity in adult females exposed to TCDD and the subsequent effects on two generations (F1 and F2) of offspring following maternal exposure.
- Results indicate significant changes in ovarian gene expression, hormonal levels (increased estradiol), and serious structural damage to ovaries, leading to reduced fertility and altered sex ratios across generations.