Incomplete recovery of erectile function in rat after discontinuation of dual 5-alpha reductase inhibitor therapy.

Aim: The association of 5-alpha reductase inhibitor (5ARI) therapy and sexual dysfunction has been reported. Some patients claim persistent erectile dysfunction despite long-term discontinuation of 5ARI treatment. The aim of this study was to assess erectile function after cessation of 5ARI therapy using a rat model.

Imatinib mesylate (Gleevec) as protein-tyrosine kinase inhibitor elicits smooth muscle relaxation in isolated human prostatic tissue.

Objective: To evaluate the mechanism of action of imatinib mesylate (Gleevec), a protein tyrosine kinase inhibitor on the human prostate with benign prostatic hyperplasia.

Methods: Prostate samples were obtained from 16 patients with benign prostatic hyperplasia (mean age 68.3 ± 1.