Publications by authors named "Nouf Al-Fadel"
Signal Detection and Assessment of Herb-Drug Interactions: Saudi Food and Drug Authority Experience.
Drugs Real World Outcomes
December 2023
Introduction: Numerous investigations on herbal medicine that have been undertaken in the past several years demonstrate the general acceptance of its safety. The Saudi Food and Drug Authority (SFDA) established the Herb-Drug Interaction (HDI) project to detect and assess potential HDIs to ensure safety. The aim is to detect safety signals and assess them based on available evidence.
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- * Patients using infliximab showed a significant increase in TB screening rates post-RMM implementation, with chest X-ray tests rising from 7.5% to 13.8% and QuantiFERON tests from 4.5% to 24.1%.
- * Despite improvements, TB screening remained inadequate prior to starting infliximab or adalimumab, indicating a need for further investigation into the reasons behind low adherence to testing protocols.
The lack of inclusion of pregnant women in clinical trials evaluating the effectiveness of medicines to treat COVID-19 has made it difficult to establish evidence-based treatment guidelines for pregnant women. Our aim was to provide a review of the evolution and updates of the national guidelines on medicines used in pregnant women with COVID-19 published by the obstetrician and gynecologists' societies in thirteen countries in 2020-2022. Based on the results of the RECOVERY (Randomized Evaluation of COVID-19 Therapy) trial, the national societies successively recommended against prescribing hydroxychloroquine, lopinavir-ritonavir and azithromycin.
View Article and Find Full Text PDFPreterm birth (PTB) is a leading cause of neonatal morbidity and mortality. To estimate the effect of 17-alpha-hydroxyprogesterone caproate (17-OHPC) compared to placebo in singleton gestations for reducing the risk of recurrent PTB and neonatal morbidity and mortality. Systematic review and meta-analysis.
View Article and Find Full Text PDFBackground: There is a risk of adverse neurodevelopmental outcomes in offspring from exposure to antidepressants during pregnancy.
Objective: This study was performed to systematically review the available evidence regarding the impact of in utero exposure to antidepressants on motor and intellectual disability outcomes in children.
Patients And Methods: A systematic literature search for published observational studies examining the effects of antidepressants on motor development or intellectual disabilities in children was conducted using the Cochrane Central Register of Controlled Trials, PubMed/Medline, and Google Scholar.
Objectives: To evaluate implementation of safety standards of compounded sterile preparations in different hospitals.
Methods: This cross-sectional study included 124 hospitals from 19 countries. A survey was developed based on the guidelines and safety practices of the Institute for Safe Medication Practices (ISMP) for sterile preparations compounding, and was sent to the members of the Intravenous and Parenteral Nutrition experts' network (IV PN experts' network) in the Gulf region and beyond using SurveyMonkey software.