Publications by authors named "Nouf Al Rashed"
Background: Acinetobacter baumannii is a serious health concern worldwide, causing high mortality rates and limited medical therapy options. Carbapenem resistance is a significant problem in Acinetobacter baumannii isolates. The synthesis of acquired carbapenemases, such as oxacillinases, IMP, NDM, VIM, and KPC enzymes, causes carbapenem resistance.
View Article and Find Full Text PDFArticle Synopsis
- Carbapenem-resistant Acinetobacter baumannii (CRAB) is a major concern in hospitals, with increasing mortality rates and recently recognized by WHO as a global health threat, especially in Bahrain where data is scarce.
- A study collected 50 CRAB isolates from four hospitals, examining their antibiotic resistance using the BD Phoenix and VITEK-2 systems, and screened for resistance markers through PCR.
- Results showed 100% resistance to imipenem and a high prevalence of class D carbapenemases, highlighting the urgent need for improved infection control and surveillance to combat the spread of these resistant bacteria.
Detection of Overexpression of Efflux Pump Expression in Fluoroquinolone-Resistant Isolates.
Int J Appl Basic Med Res
January 2020
Context: Fluoroquinolones are the most effective antibiotics against ; many strains, however, have shown resistance due to mutations in DNA gyrase, topoisomerase IV, or in the efflux pumps. Little is known about efflux pump resistance mechanisms in the Kingdom of Bahrain.
Aim: The aim was to study efflux pump-mediated fluoroquinolone resistance among isolates using phenotypic (E-test and agar dilution) and genotypic (real-time-polymerase chain reaction [RT-PCR]) methods.
Introduction: Carbapenem-resistant has emerged as a life-threatening infectious agent worldwide. Carbapenemase genes are reported to be some of the most common mechanisms for carbapenem resistance in . No reports are available from the Kingdom of Bahrain about carbapenem resistance and the underlying cause.
View Article and Find Full Text PDF