Delta-9 desaturase reduction in gastrointestinal cells induced to senescence by doxorubicin.

The condition of cellular senescence has specific features, including an altered lipid metabolism. Delta-9 desaturase (Δ9) catalyzes the conversion of saturated fatty acids, such as palmitic acid and stearic acid, into their monounsaturated forms, palmitoleic and oleic acid, respectively. Δ9 activity is important for most lipid functions, such as membrane fluidity, lipoprotein metabolism and energy storage.

Assessing a binary quantum channel exploiting a silicon photomultiplier based hybrid receiver.

In quantum communication protocols, the use of photon-number-resolving detectors could open new perspectives by broadening the way to encode and decode information and merging the properties of discrete and continuous variables. In this work, we consider a quantum channel exploiting a silicon-photomultiplier-based receiver and evaluate its performance for quantum communication protocols under three possible configurations, defined by different post-processing of the detection outcomes. We investigate two scenarios: information transmission over the channel, quantified by the mutual information, and continuous-variable quantum key distribution, quantified by the key generation rate.

Metataxonomics and Metabolomics Profiles in Metabolic Dysfunction-Associated Fatty Liver Disease Patients on a "Navelina" Orange-Enriched Diet.

Background/objectives: Metabolic dysfunction-associated fatty liver disease (MAFLD) is currently the most common cause of chronic liver disease. Systemic inflammatory status and peripheral metabolic symptoms in the clinical picture have an impact on gut commensal bacteria.

Methods: Our designed clinical trial was based on a cohort of patients with MAFLD whose diet included the daily consumption of 400 g of "Navelina" oranges for 28 days, compared with a control group of patients with the same pathologic conditions whose diet did not include the consumption of oranges and other foods containing similar nutrients/micronutrients.

Daily Orange Consumption Reduces Hepatic Steatosis Prevalence in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: Exploratory Outcomes of a Randomized Clinical Trial.

: Consumption of flavonoid-rich orange juice has been shown to reduce adiposity and liver steatosis in murine models of diet-induced obesity. However, little is known about the effects of whole orange intake, independent of body weight changes, on liver function and steatosis in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). The goal is to understand the direct impact of orange consumption on metabolic health.

Relationship between Markers of Gut Barrier Function and Erythrocyte Membrane PUFAs in Diarrhea-Predominant IBS Patients Undergoing a Low-FODMAP Diet.

Many patients with irritable bowel syndrome (IBS) have a compromised intestinal barrier associated with low-grade inflammation. Polyunsaturated fatty acids (PUFAs) are potential mediators of inflammation: omega-6 PUFAs are pro-inflammatory, while omega-3 PUFAs are antioxidant and anti-inflammatory. Zonulin is a potential biomarker for small intestinal permeability (s-IP).

Bio-Based Materials as a Sustainable Solution for the Remediation of Contaminated Marine Sediments: An LCA Case Study.

Contaminated sediments may induce long-term risks to humans and ecosystems due to the accumulation of priority and emerging inorganic and organic pollutants having toxic and bio-accumulation properties that could become a secondary pollution source. This study focused on the screening of novel bio-based materials to be used in the decontamination of marine sediments considering technical and environmental criteria. It aimed to compare the environmental impacts of cellulose-based adsorbents produced at lab scale by using different syntheses protocols that involved cellulose functionalization by oxidation and branching, followed by structuring of an aerogel-like material via Soxhlet extraction and freeze-drying or their combination.

Ex Situ Stabilization/Solidification Approaches of Marine Sediments Using Green Cement Admixtures.

The routine dredging of waterways produces huge volumes of sediments. Handling contaminated dredged sediments poses significant and diverse challenges around the world. In recent years, novel and sustainable ex situ remediation technologies for contaminated sediments have been developed and applied.

Strategies to enhance the circularity of non-bottle PET packaging waste based on a detailed material characterisation.

The compositions of Dutch lightweight packaging waste (LWP) and sorted products named "PET (Polyethylene terephthalate) trays" have been determined on object level. Additionally, the PET trays from both waste types were sorted in 16 categories representing their packaging use and material build-up. The material composition of at least 10 representative trays from each category was determined with chemical and thermal analysis, based on which the average material composition per category was established.

Recovery of Plastics from WEEE through Green Sink-Float Treatment.

Increasing demand for electrical and electronic equipment results in the generation of a rapidly growing waste stream, known by the acronym WEEE (waste electrical and electronic equipment). The purpose of this study was to evaluate the effectiveness of green sink-float treatment in sorting plastic polymers typically found in WEEE (PP, ABS, PA6, PS, and PVC). Molasses, a by-product of sugar bio-refining, was added in various concentrations to water to form solutions at different densities.

Significant Increase in Oxidative Stress Indices in Erythrocyte Membranes of Obese Patients with Metabolically-Associated Fatty Liver Disease.

Metabolic dysfunction-associated hepatic steatosis (MAFLD) indicates the metabolic risk associated with hepatic steatosis, overweight and obesity, and clinical evidence of metabolic dysregulation. Since MAFLD is one of the diseases that show a high frequency of alterations in the lipid content of cell membranes, the aim of this study was to evaluate the indices of oxidative damage of erythrocyte membranes in overweight and obese MAFLD subjects. The study was conducted on serum samples and red blood cell membranes of overweight and obese MAFLD subjects.

Contribution of Nutritional, Lifestyle, and Metabolic Risk Factors to Parkinson's Disease.

Background: Modifiable risk factors for Parkinson's disease (PD) are poorly known.

Objectives: The aim is to evaluate independent associations of different nutritional components, physical activity, and sedentary behavior and metabolic factors with the risk of PD.

Methods: In this population-based prospective cohort study using the data of the United Kingdom Biobank (from 2006-2010), 502,017 men and women who were free from PD (International Classification of Diseases 10th edition; "G20") at baseline were included.

Semaglutide Modulates Extracellular Matrix Production of LX-2 Cells via Exosomes and Improves Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).

Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely related to some metabolic disorders, such as central obesity and type 2 diabetes (T2D). Glucagon-like peptide 1 receptor agonists (GLP-1RAs), such as semaglutide, may have therapeutic roles in MASLD associated with T2D. This study aims to investigate the molecular mechanisms underlying the effectiveness of semaglutide on MASLD in terms of progression from liver steatosis to fibrosis.

Recent developments and prospects of sustainable remediation treatments for major contaminants in soil: A review.

Rapid industrialisation and urbanisation are contributing to the entry of emerging contaminants into the environment, posing a significant threat to soil health and quality. Therefore, several remediation technologies have been investigated and tested at a field scale to address the issue. However, these remediation technologies face challenges related to cost-effectiveness, environmental concerns, secondary pollution due to the generation of by-products, long-term pollution leaching risks, and social acceptance.

Serum Cytokine and miRNA Levels Are Differently Expressed in Right- and Left-Sided Colon Cancer.

The tumor location in colorectal cancer (right- or left-sided colon cancer) is a key factor in determining disease progression. Right- and left-sided colon tumors are different in their clinical and molecular characteristics. Dysregulation of serum levels of proinflammatory cytokines, such as Transforming Growth Factor β (TGF-β) and Tumor Necrosis Factor-α (TNF-α), and Peroxisome Proliferator Activated Receptor-γ (PPAR-γ), known to be a growth-limiting and differentiation-promoting factor, as well as changes in miRNAs expression, are the major signaling pathways involved in the pathogenesis of this neoplasia.

Effect of Cellulose-Based Bioplastics on Current LDPE Recycling.

The increased use of bioplastics in the market has led to their presence in municipal solid waste streams alongside traditional fossil-based polymers, particularly low-density polyethylene (LDPE), which bioplastics often end up mixed with. This study aimed to assess the impact of cellulose acetate plasticized with triacetin (CAT) on the mechanical recycling of LDPE. LDPE-CAT blends with varying CAT content (0%, 1%, 5%, 7.

Corrigendum: Correlation between antioxidant and anticancer activity and phenolic profile of new Apulian table grape genotypes ( L.).

[This corrects the article DOI: 10.3389/fpls.2022.

Recycling of Contaminated Marine Sediment and Industrial By-Products through Combined Stabilization/Solidification and Granulation Treatment.

Stabilization/solidification (S/S) is becoming increasingly important, as it allows the remediation of contaminated sediments and their recovery into materials for civil engineering. This research proposes a cement-free cold granulation process for manufactured low-cost aggregates from marine sediments contaminated with organic compounds and metals. After the chemo-physical characterization of the study materials, two mix designs were prepared in a rotary plate granulator by adding two industrial by-products as geopolymer precursors, coal fly ash (CFA) and Blast Furnace Slag (BFS), but also alkaline activation solutions, water, and a fluidizer.

Environmental Sustainable Cement Mortars Based on Polyethylene Terephthalate from Recycling Operations.

The building and construction industry is a key sector behind the ecological transition in that it is one of the main responsible factors in the consumption of natural resources. Thus, in line with circular economy, the use of waste aggregates in mortars is a possible solution to increase the sustainability of cement materials. In the present paper, polyethylene terephthalate (PET) from bottle scraps (without chemical pretreatment) was used as aggregate in cement mortars to replace conventional sand aggregate (20%, 50% and 80% by weight).