Publications by authors named "Noshin Tasnim Yana"

Linalool (LIN) has some important neuropharmacological activities, including anxiolytic and sedative effects. It is also clear that it protects experimental animals from convulsions and Alzheimer's disease. On the other hand, caffeine (CAF) and sclareol (SCL) have neurostimulatory potential.

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The citrus peel flavonoid tangeretin (TAN) has diverse biological activities, including antioxidant, anti-inflammatory, antitumor, hepatoprotective, and neuroprotective effects. This study investigates the sedative effects of TAN, in Swiss albino mice using in vivo and in silico approaches. TAN (10 and 20 mg/kg, i.

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Prunetin (PRU), a naturally occurring flavonoid, has gained recognition for its wide-ranging therapeutic benefits, though its anticancer properties have yet to be extensively reviewed. This study explores the potential of PRU in targeting critical molecular pathways involved in tumor progression, including oxidative stress, apoptosis, cell cycle regulation, and metastasis. Data were compiled from reputable sources, including PubMed, Springer Link, Scopus, Wiley Online, Web of Science, ScienceDirect, and Google Scholar.

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Oleuropein (OLP), a compound predominantly found in olive leaves, has been known for its numerous biological activities, including antioxidant, anti-inflammatory, and antimicrobial properties. Despite its established therapeutic potential, its role in treating diarrhea has not been extensively explored. This study aimed to evaluate the antidiarrheal effects of OLP in an in vivo model and to investigate its molecular interactions using in silico docking studies, pharmacokinetic predictions, and toxicity analysis.

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Article Synopsis
  • This study investigates the pain-relieving (analgesic) and anxiety-reducing (anxiolytic) effects of citronellal (CTL) in Swiss mice using innovative, cost-effective models.
  • Results showed that CTL significantly decreased various anxiety and pain-related behaviors in mice compared to a control group, even outperforming standard drugs like diclofenac sodium in some tests.
  • In addition, in silico studies suggested that CTL interacts with specific receptors (GABA) and enzymes (COX), indicating its potential as an effective anxiolytic and analgesic agent through these molecular pathways.
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Sleep disturbance causes many health problems in humans worldwide. This study evaluated the effects and possible mechanisms of sclareol (SCL) and/or linalool (LIN) through in vivo and in silico studies. For this, young chicks SCL (5, 10, and 20 mg/kg) and/or LIN (50 mg/kg) were orally administered thirty minutes before to the thiopental sodium (TS)-induced chicks with or without the standard drug diazepam (DZP: 3 mg/kg).

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Article Synopsis
  • - The study investigates the anti-inflammatory properties of piperine (PPN) by inducing inflammation in young chicks and administering PPN with various other drugs to compare effects.
  • - Results show that PPN effectively reduces inflammation indicators, like licking frequency and paw swelling, in a dose-dependent manner; however, it also reduces the effectiveness of concurrent medications celecoxib (CXB) and ketoprofen (KPN).
  • - PPN demonstrates a strong binding affinity to the COX-2 enzyme, suggesting its mechanism of action involves COX-2 inhibition, leading to its anti-inflammatory effects in chicks while competing with other anti-inflammatory drugs.
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