Publications by authors named "Nosakhare P Ilerhunmwuwa"
Diffuse large B-cell Lymphoma (DLBCL) is an aggressive subtype of non-Hodgkin lymphoma (NHL). The disease generally occurs in older patients. Although at a lower prevalence, the disease also occurs in the adolescent and young adult group (AYA).
View Article and Find Full Text PDFBackground: Prior systematic reviews addressing the impact of diet on cancer outcomes have focused on specific dietary interventions. In this systematic review, we assessed all randomized controlled trials (RCTs) investigating dietary interventions for cancer patients, examining the range of interventions, endpoints, patient populations, and results.
Methods: This systematic review identified all RCTs conducted before January 2023 testing dietary interventions in patients with cancer.
Lurbinectedin, a novel antineoplastic agent, was granted the orphan drug designation by the United States Food and Drug Administration (US FDA) and approved for use in relapsed/refractory small cell lung cancer in June 2020. The approval was granted after its efficacy was demonstrated in a multicenter open-label, multi-cohort study enrolling 105 participants. Since then, real-world studies have examined the efficacy and safety profiles of lurbinectedin in clinical practice.
View Article and Find Full Text PDFSarcoidosis is a multisystem granulomatous disorder of unknown etiology characterized by non-caseating granulomas in involved organs. Approximately 10% of patients with sarcoidosis exhibit central nervous system involvement. However, the occurrence of isolated neurosarcoidosis without concurrent systemic signs is very rare, affecting less than 1% of patients.
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- COVID-19 significantly impacts patients with sickle cell disease (SCD), yet limited data exists on how different hemoglobin (Hb) genotypes affect infection outcomes.
- Researchers analyzed hospitalized COVID-19 cases in SCD patients from the National Inpatient Sample, focusing on various treatment and mortality outcomes across different Hb genotypes (HbSS, HbSC, and HbSβ).
- The study found that while HbSS was the most common genotype, there were no significant differences in in-hospital outcomes among the genotypes, indicating a need for further research to understand this finding.
Background: Pituitary metastasis (PM) from differentiated thyroid cancer (DTC) is extremely rare and may adversely affect outcomes. We aimed to assess the characteristics and outcomes of patients with PM from DTC.
Methods: We systematically reviewed the literature on publications on PM and the different DTC histologic types (papillary, follicular, and Hurthle cell cancers).
Article Synopsis
- - The study investigates the prevalence and outcomes of pulmonary embolism (PE) in patients with sickle cell disease (SCD), finding that out of 405,020 patients with PE, only 1,504 (0.4%) had SCD.
- - SCD patients were predominantly female and Black, had lower comorbidity rates, but experienced higher in-hospital mortality (41%) and lower rates of advanced treatments like catheter-directed thrombolysis and mechanical thrombectomy.
- - The findings stress the need for healthcare providers to be more vigilant in diagnosing PE in patients with SCD to potentially lower their high in-hospital mortality rates.
Introduction: There is a paucity of data on the outcomes of coronavirus disease 2019 (COVID-19) in patients with sickle cell disease (SCD) in the United States. We examined the outcomes of patients with COVID-19 and SCD.
Methods: We utilized the National Inpatient Sample (NIS) to identify the data of patients diagnosed with COVID-19 and SCD in 2020 using the International Classification of Disease, Tenth Revision codes.
Article Synopsis
- Bradycardia, renal failure, AV nodal disease, shock, and hyperkalemia (BRASH) syndrome is a clinical condition characterized by specific symptoms including bradycardia and shock, often linked to other medical issues like hypertension or diabetes.
- An 89-year-old female with a history of hypertension and diabetes presented with severe bradycardia (heart rate of 25 beats per minute) and low blood pressure (50 mmHg systolic) after starting labetalol and suffering from gastroenteritis.
- After treatment with fluids and atropine, her condition improved significantly, leading to the diagnosis of BRASH syndrome, which typically has a good prognosis if recognized and treated early.
An 82-year-old woman admitted following a 4-week history of feeling unwell, abdominal pain and constipation. Initial investigations revealed severe hypercalcaemia with suppressed parathyroid hormone and elevated 1,25-dihydroxycholecalciferol. ACE was also raised.
View Article and Find Full Text PDFAn 85-year-old man was referred to endocrinology following the discovery of an incidental pituitary mass on cranial imaging which was thought to be a non-functioning adenoma during an admission with headaches, lethargy, confusion and hyponatraemia. He had a history of Hürthle cell carcinoma of the thyroid treated with total thyroidectomy, ablative radioiodine therapy and thyroxine replacement. Subsequently, he developed metastatic spread to the neck, lungs and skeleton.
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