Direct-Pathway Spiny Projection Neuron Inhibition Evokes Transient Circuit Imbalance Manifested as Rotational Behavior.

The striatum collects and integrates information from many different areas of the brain and propels this forward to the basal ganglia (BG) output structures. In this way, the striatum is playing a pivotal role in control of voluntary movements and is implicated in debilitating movement disorders such as Parkinson's disease. The functional backbone of the striatum is represented by direct pathway (dSPN) Drd1-expressing and indirect pathway (iSPN) Drd2-expressing spiny projection neurons (SPN), exerting opposite effects on movement.

Dynamic, temperature-sensitive association of 125-i-nerve growth factor in vitro with ganglionic and non-ganglionic cells from embryonic chick.

125-I-NGF was found to associate with embryonic chick dorsal root ganglia (DRG) through two processes. A time-saturable process included the binding of NGF to surface receptors with an apparent affinity constant in the range of 10(-7)M minus 1 and at a level of 4 f moles/mug tissue protein. The second process was time-linear, temperature-sensitive, and included both bound and non-competable NGF.