Publications by authors named "Norma Morales-Rochlin"

Article Synopsis
  • Recent studies indicate changes in immune regulation for individuals with irritable bowel syndrome (IBS) and differences in cytokine gene variations.
  • The research aimed to compare the IL-10 (-1082G/A) and TNF-alpha (-308G/A) gene polymorphisms between IBS patients and healthy controls in Mexico.
  • Results showed no significant differences in the gene frequencies between IBS patients and controls, but a higher occurrence of low IL-10 producers was found in the IBS-D subgroup, indicating a possible genetic link to immune regulation issues in this population.
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Objectives: Studies suggest that altered immune activation, manifested by an imbalance in anti- and pro-inflammatory cytokine levels, exists in a subgroup of irritable bowel syndrome (IBS) patients. However, similar studies have not been conducted in Latin populations. The objective of this study was to measure serum levels of interleukin (IL)-10 and tumor necrosis factor (TNF)-α in subjects fulfilling symptom criteria for IBS and controls.

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