Neurobiological approaches of high-fat diet intake in early development and their impact on mood disorders in adulthood: A systematic review.

The early stage of development is a vulnerable period for progeny neurodevelopment, altering cytogenetic and correct cerebral functionality. The exposure High-Fat Diet (HFD) is a factor that impacts the future mental health of individuals. This review analyzes possible mechanisms involved in the development of mood disorders in adulthood because of maternal HFD intake during gestation and lactation, considering previously reported findings in the last five years, both in humans and animal models.

A high-fat diet during pregnancy impairs memory acquisition and increases leptin receptor expression in the hippocampus of rat offspring.

A high-fat diet (HFD) during pregnancy influences the neurodevelopment of progeny, particularly in the hippocampus, a brain region involved in cognitive processes. The hippocampus has high levels of leptin receptors (Ob-R) that participate in synaptic plasticity. This study examined the effect of maternal HFD during gestation on Ob-R expression in the CA1 and CA3 hippocampal regions, and its relationship with spatial learning and memory in the offspring.

[Alpha-tocopherol and alpha-lipoic acid. An antioxidant synergy with potential for preventive medicine].

Reactive oxygen species (ROS) have been involved in the induction and progression of damage of many human disorders, such as: heart infarction, cerebral ischemia, diabetic neuropathy, Alzheimer's disease, etc. In several studies, the synergism between alpha-lipoic acid and vitamin E has been described and potent antioxidant effects can be obtained when both antioxidants are simultaneously used. This review highlights recent findings showing that the combination of alpha-lipoic acid plus vitamin E effectively reduces oxidative damage in brain and cardiac ischemia as well as in other pathological events related to ROS increasing.