The Inhibition of Hepatic and Renal Glucuronidation of -Nitrophenol and 4-Methylumbelliferone by Oil Palm Empty Fruit Bunch Lignin and Its Main Oxidation Compounds.

Background: In order to develop oil palm empty fruit bunch (EFB) lignin as a nutraceutical and health supplement, the investigation of its potential in interacting with other drugs via inhibition of drug-metabolizing enzymes (DMEs) would ensure product safety.

Objective: The study was aimed to investigate the effect of oil palm EFB lignin and its main oxidation compounds on phase II DME UDP-glucuronosyltransferases (UGTs) in rat liver and kidney microsomes.

Materials And Methods: The -nitrophenol (-NP) and 4-methylumbelliferone (4-MU) were employed as probe substrates in glucuronidation assays.