Publications by authors named "Norlelawati Abdul Talib"
: The link between rheumatoid arthritis (RA) and schizophrenia (SZ) has long been a hot topic of deliberation among scientists from various fields. Especially when it comes to genetics, the connection between RA and SZ is still up for discussion, as can be observed in this study. The HLA genes are the most disputed in identifying a connection between the two diseases, but a more thorough investigation of other genes that may be ignored could yield something even more interesting.
View Article and Find Full Text PDFEvaluation of mutation effects on UGT1A1 activity toward 17beta-estradiol using liquid chromatography-tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci
June 2006
Article Synopsis
- - The study investigates how mutations in the UGT1A1 gene affect its ability to process substances like estradiol and bilirubin through a method called liquid chromatography-tandem mass spectrometry (LC/MS/MS).
- - Researchers looked at specific mutations (G71R, F83L, I322V, G493R) and found that their enzymatic activities were significantly lower than normal, with G493R showing only 0.6% activity.
- - Utilizing LC/MS/MS allowed the team to accurately measure how these mutations impacted the UGT1A1's effectiveness in forming estradiol glucuronides.