Publications by authors named "Noriyuki Kurimoto"
J Gastroenterol Hepatol
June 2023
Article Synopsis
- Ustekinumab is effective for treating Crohn's disease, but many patients lose response within 2 years, prompting this study to evaluate its long-term efficacy and predictability.
- The study included 59 patients and found that only 38.2% had a clinical response at week 8; factors linked to loss of efficacy included baseline disease severity and certain cytokine levels.
- It was concluded that measuring serum MCP-1 levels and knowing a patient's biologic treatment history could help predict the effectiveness of ustekinumab over time.
Article Synopsis
- Endoscopic mucosal healing is a key treatment target for ulcerative colitis (UC) patients, and the neutrophil-to-lymphocyte ratio (NLR) serves as a potential marker for predicting relapses.
- A study conducted on 129 UC patients with low Mayo Endoscopic Subscores found that those with higher NLRs had a significantly lower relapse-free rate compared to those with lower NLRs over a follow-up period of about 46 months.
- The findings suggest that the NLR can be a valuable tool in clinical settings for identifying patients at risk of relapse and guiding treatment strategies.
