Publications by authors named "Noritomo Izumi"
Article Synopsis
- The study aimed to explore how atorvastatin and grapefruit juice affect the pharmacokinetics of certain drugs that are processed by OATP2B1 and BCRP in healthy volunteers.
- Results indicated that grapefruit juice significantly decreased the absorption of the test drugs compared to a control phase, suggesting all five drugs are processed by OATP2B1, while atorvastatin did not have a similar effect.
- Genetic factors, specifically the ABCG2 c.421C>A polymorphism, influenced the levels of sulfasalazine and rosuvastatin absorbed, while the SLCO2B1*3 genotype did not affect the pharmacokinetics of any of the tested drugs.
Article Synopsis
- - A variant in the BCRP gene (421C>A) helps explain differences in how individuals metabolize the drug sulfasalazine (SASP), but there are still variations among people with the same genetic variant.
- - Researchers propose that levels of exosomal miR-328, found in plasma and influenced by intestinal leakage, could serve as a biomarker for assessing the activity of BCRP in the intestines.
- - In a study with 33 healthy participants, higher levels of intestine-derived miR-328 were linked to increased SASP exposure, indicating lower BCRP activity, highlighting its potential as a biomarker for BCRP function.
We investigated the mechanisms of ritonavir-mediated enhancement effect on the pharmacokinetics of saquinavir using in vivo probes for CYP3A4 (midazolam), p-glycoprotein (fexofenadine), and OATP1B1 (pravastatin) following oral micro/small dosing. A cocktail of the drugs (2 mg of saquinavir, 100 µg of each probe) was administered to eight healthy volunteers (phase 1), and then coadministered with 20 mg (phase 2) and 100 mg (phase 3) of ritonavir. Plasma concentrations of the drugs were measured by validated LC-MS/MS methods.
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