Cu-Catalyzed Asymmetric Arylation of Enone Diesters with Arylboronic Acids.

The Cu-catalyzed asymmetric conjugate addition of arylboronic acids to enone diesters is reported. This operationally simple and scalable reaction proceeded under mild conditions. The practical utility of this approach was demonstrated by the synthesis of structurally important γ-lactones and a cyclopentene that bear an aryl group.

Cu-Catalyzed Asymmetric Alkenylation of Enone Diesters with Trialkenylboroxines.

The Cu-catalyzed asymmetric conjugate addition of trialkenylboroxines to enone diesters is reported. This operationally simple and scalable reaction proceeded at room temperature, and a wide range of enone diesters and boroxines were tolerated under the applied reaction conditions. The practical utility of this approach was demonstrated via the formal synthesis of (+)-methylenolactocin.