Using artificial intelligence and promoter-level transcriptome analysis to identify a biomarker as a possible prognostic predictor of cardiac complications in male patients with Fabry disease.

Fabry disease is the most frequently occurring form of lysosomal disease in Japan, and is characterized by a wide variety of conditions. Primarily, the three major types of concerns associated with Fabry disease observed during adulthood that must be prevented are central nervous system, renal, and cardiac complications. Cardiac complications, such as cardiomyopathy, cardiac muscle fibrosis, and severe arrhythmia, are the most common mortality causes in patients with Fabry disease.

Silyliumylidene Ion Stabilized by Two σ-Donating Ni(0)- and Pd(0)-Fragments.

A silyliumylidene ion 2 stabilized by two σ-donating Ni(0)- and Pd(0)-fragments was successfully synthesized. Due to the σ-donation of M→Si interactions, 2 presents a pyramidalized cationic silicon center with a localized lone pair. The additional coordination of basic Pd(0) fragment to the mono-Ni(0)-stabilized silyliumylidene 1 results in a higher HOMO level and an unchanged HOMO-LUMO gap and thus, 2 remains highly reactive.

Syntheses of Iminophosphomamido Chlorogermylenes and Their Complexation with a Rhodium(I) Complex.

Three-coordinated chlorogermylenes of the type [Ph P(RN) ]GeCl (3: R= Bu; 4: R=Dip=2,6- Pr C H ), which bear an N,N-substituted iminophosphonamide ligand, were synthesized. The coordination behavior of 3 and 4 toward rhodium(I) complex was investigated. When 3 was treated with 1/2 of an equivalent of [RhCl(cod)] (cod=1,5-cyclooctadiene), the corresponding chlorogermylene-Rh(I) complex 5 was obtained as orange crystals.

Synthesis of a homoleptic tris(silylene)-palladium(0) complex and a silylyne-bridged tetranuclear palladium cluster.

We report the reactions of an iminophosphonamido-silylene (1) with different palladium complexes. The reaction of 1 with [Pd(PPh)] furnished a homoleptic tris(silylene)-palladium(0) complex. In contrast, treatment of 1 with [PdMe(tmeda)] led to the unprecedented formation of a non-planar -silylyne-bridged tetranuclear palladium cluster that contains palladium atoms in different oxidation states.

Niobium Complexes Supported by Chalcogen-Bridged [OEO]-Type Bis(phenolate) Ligands (E = S, Se): Synthesis, Characterization, and Phenylacetylene Polymerization.

Trichloro niobium(V) complexes and with the sulfur- or selenium-bridged [OEO]-type bis(phenolate) ligands (E = S, Se) were synthesized and fully characterized on the basis of their NMR spectroscopic data and X-ray crystallographic analysis. In the crystalline state of , the [OSeO]-core of the ligand was coordinated to the niobium center in a -fashion. The corresponding tribenzyl niobium(V) complexes and were also prepared by the reactions of and with 3 equivalents of PhCHMgCl in toluene.

Ensemble Learning of Multiple Models Using Deep Learning for Multiclass Classification of Ultrasound Images of Hepatic Masses.

Ultrasound (US) is often used to diagnose liver masses. Ensemble learning has recently been commonly used for image classification, but its detailed methods are not fully optimized. The purpose of this study is to investigate the usefulness and comparison of some ensemble learning and ensemble pruning techniques using multiple convolutional neural network (CNN) trained models for image classification of liver masses in US images.

In vitro study about prevention of vascular reocclusion by low intensity ultrasonic irradiation.

For the treatment of acute ischemic stroke, the current standard of care is thrombolysis by the administration of intravenous (IV) recombinant tissue-type plasminogen activator (rt-PA). Although this approach is proven to be effective, reocclusion within 24 hours occurs in about 20% of patients who receive recanalization by rt-PA. In addition, the administration of anticoagulants within 24 hours after IV rt-PA increases the risk of intracranial hemorrhage; therefore, treatment with anticoagulants is contraindicated in this population.

Iminophosphonamido-Supported Plumbylenes and Plumbyliumylidenes: Synthesis and Properties.

A series of low-valent lead(II) species, i.e., plumbylenes and plumbyliumylidenes supported by an ,'-di--butyliminophosphonamide ligand, have been synthesized.

Detection of Sacral Fractures on Radiographs Using Artificial Intelligence.

Unlabelled: Sacral fractures are often difficult to diagnose on radiographs. Computed tomography (CT) and magnetic resonance imaging (MRI) can improve the detection rate but cannot always be performed. The accuracy of artificial intelligence (AI) in detecting orthopaedic fractures is now comparable with that of orthopaedic specialists.

Halogen-Exchange Reactions of Iminophosphonamido-Chlorosilylenes with Alkali Halides: Convenient Synthesis of Heavier Halosilylenes.

Halogen-substituted silylenes are an important building block for synthesizing silicon-based low-valent and multiple-bond species. However, the number of reports on heavier halosilylenes that contain bromine and iodine is still limited. Here, we present a convenient synthesis for bromo- and iodosilylenes supported by an iminophosphonamide ligand.

Hydroboration of carbonyls and imines by an iminophosphonamido tin(II) precatalyst.

A novel three-coordinated tin(II) chloride [PhP(NBu)]SnCl (1) supported by an ,'-di--butyliminophosphonamide having two phenyl groups on the phosphorus atom was synthesized by the reaction of the starting lithium iminophosphonamide [PhP(NBu)]Li with SnCl·(dioxane) in toluene. The molecular structure of 1 was established by X-ray diffraction analysis. Tin(II) chloride 1 can act as an efficient precatalyst for the hydroboration of a wide variety of aldehydes, ketones, and imines at -10 °C.

Formation of silaimines from a sterically demanding iminophosphonamido chlorosilylene intramolecular N-P bond cleavage.

The sterically demanding iminophosphonamido chlorosilylene [Ph2P(DipN)2]SiCl (Dip = 2,6-diisopropylphenyl) was synthesized and fully characterized using NMR spectroscopy and X-ray crystallography. Substitution reactions of [Ph2P(DipN)2]SiCl with N- and Fe-nucleophiles led to the unexpected formation of the corresponding silaimine derivatives. This process involves the ring-opening rearrangement of three-coordinated silylene intermediates that proceeds via intramolecular N-P bond cleavage.

Strained and Reactive Donor/Acceptor-Supported Metallasilanone.

A novel stable donor/acceptor-supported Mn -metallasilanone 3 was synthesized. The intramolecular silanone-Mn interaction induces a highly strained three-membered cyclic structure, leading to an exceptionally high reactivity of 3 as a donor/acceptor complex of silanone. Indeed, metallasilanone 3 readily reacts with various small molecules such as H or ethylene gas in mild conditions.

Interconversion between a silaimine and an aminosilylene supported by an iminophosphonamide ligand.

The reaction of a chlorosilylene, supported by an iminophosphonamide ligand, with KN(SiMe) resulted in the formation of a silaimine instead of the expected aminosilylene. However, this silaimine exists in equilibrium with the corresponding aminosilylene, which was experimentally demonstrated using variable-temperature NMR spectroscopy and a trapping reaction with elemental selenium to give a silaselenourea.

An Iminophosphonamido-Chlorosilylene as a Strong σ-Donating NHSi Ligand: Synthesis and Coordination Chemistry.

The N-heterocyclic silylene (NHSi) [Ph P( BuN) ]SiCl (1), supported by an iminophosphonamide ligand, was obtained from the dehydrochlorination of [Ph P( BuN) ]SiHCl (2) with LiN(SiMe ) . NHSi 1 contains an extremely high-energy HOMO level and consequently displays unique coordination behavior toward Rh complexes. When 1 was treated with 1/4 of an equivalent of [RhCl(cod)] (cod=1,5-cyclooctadiene), the 14-electron Y-shaped bis(chlorosilylene) Rh complex 5 was obtained as dark purple crystals.

Synthesis of a Stable N-Hetero-Rh -Metallacyclic Silanone.

A novel N-hetero-Rh -metallacyclic silanone 2 has been synthesized. The silanone 2, showing an extremely large dimerization energy (ΔG=+86.2 kcal mol ), displays considerable stability and persists in solution up to 60 °C.

A Stable N-Hetero-Rh-Metallacyclic Silylene.

A cyclic (amino)metal-substituted dicoordinated silylene derivative has been synthesized and fully characterized. Of particular interest is that the N-hetero-Rh -metallacyclic silylene exhibits a distorted tetrahedral geometry around the rhodium atom and a considerably shortened Si-Rh bond (2.138 Å) compared to classical Si-Rh single bonds (ca.

Recent technical development of artificial intelligence for diagnostic medical imaging.

Deep learning has caused a third boom of artificial intelligence and great changes of diagnostic medical imaging systems such as radiology, pathology, retinal imaging, dermatology inspection, and endoscopic diagnosis will be expected in the near future. However, various attempts and new methods of deep learning have been proposed in recent years, and their progress is extremely fast. Therefore, at the initial stage when medical artificial intelligence papers were published, the artificial intelligence technology itself may be old technology or well-known general-purpose common technology.

DEVELOPMENT OF RADIATION DOSE CALCULATION SOFTWARE USING THE SIZE-SPECIFIC DOSE ESTIMATE.

We aimed to develop a software for facilitating absorbed dose per pixel (pixel dose) calculation using a size-specific dose estimate (SSDE). We calculated the pixel dose at nine equal points inserted into the radiophotoluminescence glass dosemeter (RPLD) and compared the pixel dose with the measured doses using RPLD. With this method, the relative errors of average pixel dose was -0.

Group 2 metal bis(arenecarbochalcogenoate)(crown ether) complexes: isolation and structural analysis.

A series of Group 2 metal bis(arenecarbochalcogenoato)(crown ether) complexes M(EE'CAr)2(L)(L')x (M = Mg, Ca, Sr, Ba; Ar = aryl; E = S, Se; E' = O, S; L = H2O or THF; L' = 15-crown-5, 18-crown-6) were synthesized and their structures were revealed by X-ray analyses. The two carbothioato ligands in Mg, Ca and Sr 15-crown-5 complexes are located on the same side of the crown ether plane, while those in Mg, Ca, Sr, and Ba 18-crown-6 compounds are on both sides of the 18-crown-6 plane (trans relative to the plane). For the Ca 15-crown-5 complex, both carbothioato ligands are connected to the central Ca ion through an oxygen atom in a monodentate manner, and the two hydrogen atoms of the coordinated water molecule are intramolecularly hydrogen-bonded with thiocarbonyl sulfur atoms.

Chlorogermylenes and -stannylenes stabilized by diimidosulfinate ligands: synthesis, structures, and reactivity.

The reaction of the lithium salt of N,N'-di-tert-butyldiimidosulfinate ([PhS(NBu)]Li) having a phenyl group on the sulphur atom with ECl·(dioxane) (E = Ge, Sn) afforded the corresponding chlorogermylene [PhS(NBu)]GeCl 1 and -stannylene [PhS(NBu)]SnCl 2, respectively. In contrast, treatment of the N,N'-bis(trimethylsilyl)diimidosulfinate ion ([PhS(NSiMe)]) with ECl·(dioxane) resulted in the unexpected formations of six-membered 1,3-bis(chlorogermylene) [PhS(NSiMe)(η-η-GeCl)[μ-NSPh(NHSiMe)] 7 and -stannylene [PhS(NSiMe)(η-η-SnCl)[μ-NSPh(NHSiMe)] 8. The structures of these chlorometallylene derivatives were fully characterized on the basis of their NMR spectroscopic data and X-ray diffraction.

Inflammatory myofibroblastic tumors of the breast with simultaneous intracranial, lung, and pancreas involvement: ultrasonographic findings and a review of the literature.

We encountered a case of inflammatory myofibroblastic tumor (IMT) of the breast with simultaneous intracranial, lung, and pancreas involvement. Here, we present the clinical imaging results and report the significance of sonographic findings of breast IMT along with a review of the literature. A 16-year-old girl with a history of subarachnoidal hemorrhage was admitted to our hospital due to tonic-clonic seizure.

Significance of perithyroidal lymph nodes in benign thyroid diseases.

Purpose: The incidences of perithyroidal lymph nodes (PTLNs) in benign thyroid diseases were investigated.

Methods: A total of 108 patients were divided into 36 with benign thyroid nodules, 33 with Hashimoto's thyroiditis, 14 with Graves' disease, 10 with hypothyroidism of undetermined etiology, nine with silent thyroiditis, and six with subacute thyroiditis. We assessed the relationships among PTLNs and these groups, thyroid volume, thyroid parenchyma echogenicity, and anti-thyroid-stimulating hormone receptor, anti-thyroglobulin, and anti-thyroid peroxidase antibodies (TRAb, TgAb, and TPOAb).

Donor-Stabilized Silylene/Phosphine-Supported Carbon(0) Center with High Electron Density.

An isolable donor-stabilized silavinylidene phosphorane was synthesized. This molecule, which can also be regarded as a new carbon(0) complex featuring a phosphine and a donor-stabilized silylene ligand, presents a central carbon atom with a remarkably high electron density (-1.82).

An uncovered risk factor of sonothrombolysis: Substantial fluctuation of ultrasound transmittance through the human skull.

Sonothrombolysis is one of the most feasible methods for enhancing clot lysis with a recombinant tissue plasminogen activator (rt-PA) in cases of acute ischemic strokes. For safe and efficient clinical practices of sonothrombolysis, accurate estimation of ultrasound transmittance through the human skull is critical. Previously, we reported substantial and periodic fluctuation of ultrasound transmittance through a bone-phantom plate following changes to ultrasound frequency, the thickness of the bone-phantom plate, and the distance between a transducer and the bone-phantom plate.