Publications by authors named "Norimi Ohashi"
Article Synopsis
- The study investigates how urinary glucose excretion relates to kidney function in diabetes patients who aren't using sodium-glucose cotransporter 2 inhibitors.
- It included 1,172 diabetes patients and found that those with high urinary glucose (≥5 g/day) had better kidney function prognosis, showing a reduced risk of significant kidney decline.
- The results also indicated that this positive association was stronger in men and in patients who had diabetes for 10 or more years, suggesting urinary glucose can help predict kidney health in these individuals.
Purpose: Amyloid-β protein (Aβ) is one of the causative proteins of Alzheimer's disease. We have been developing extracorporeal blood Aβ-removal systems as a method for enhancing Aβ clearance from the brain. We reported previously that medical adsorbents and hemodialyzers removed Aβ monomers from peripheral blood, which was associated with influx of Aβ monomers from the brain into the bloodstream.
View Article and Find Full Text PDFAims/introduction: Bullous pemphigoid (BP) might be drug-induced. The present study evaluated the relationship between BP and dipeptidyl peptidase-4 inhibitors (DPP4Is).
Materials And Methods: We recruited patients diagnosed with BP at Ogaki Municipal Hospital from 1 December 2009 through 31 December 2017.
Accumulation of amyloid-β protein (Aβ) in the brain causes cognitive impairment in Alzheimer's disease. We hypothesized that an extracorporeal system that rapidly removed Aβ from the blood may accelerate Aβ drainage from the brain. We previously reported that dialyzers remove blood Aβs effectively, mainly by adsorption on the inner surfaces of the hollow fibers, resulting in lower Aβ accumulation in the brains of patients undergoing hemodialysis than the controls without hemodialysis.
View Article and Find Full Text PDFAim: We aimed to evaluate the anti-albuminuric effects of topiroxostat in Japanese hyperuricaemic patients with diabetic nephropathy.
Methods: In this 24-week, multicentre, open-label, randomized (1 : 1) trial, we assigned hyperuricaemic patients with diabetic nephropathy (estimated glomerular filtration rate ≥ 20 mL/min per 1.73m ) and overt proteinuria (0.
Background: Data regarding the association between 24h urinary sodium and potassium excretion with kidney outcomes in patients with diabetes mellitus is currently scarce.
Methods: We conducted a single-center, retrospective cohort study in which 1230 patients with diabetes who had undergone a 24h urinary sodium and potassium excretion test were analyzed. Patients with incomplete urine collection were excluded based on 24h urinary creatinine excretion.
Article Synopsis
- Early withdrawal from peritoneal dialysis (PD) improved to 44.7% after implementing education programs for medical staff, compared to 50.9% in the previous study.
- The incidence of peritonitis increased slightly, with patients experiencing it once every 47.3 months in the recent study, showing some improvement from 42.8 months in the earlier one.
- While educational efforts reduced mortality from PD-related peritonitis, further advancements are necessary, including developing improved sterilization methods and addressing social issues causing patients to withdraw from PD therapy.
A 70-year-old woman who was diagnosed with multiple myeloma underwent chemotherapy. Three months after beginning chemotherapy, she was readmitted to the hospital because of fever and hepatopathy. Her elevated Epstein-Barr virus (EBV) antibody levels showed that the hepatopathy was caused by reactivation of EBV.
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