Publications by authors named "Noriki Okada"
Aim: To assess the preoperative disease characteristics and indications for living donor liver transplantation (LDLT), complications, patient survival, and prognosis after LDLT for fibropolycystic liver disease (FLD) in children.
Methods: We undertook a cross-sectional survey of patients who underwent LDLT for FLD between January 2002 and December 2020.
Results: A total of 35 patients (22 male and 13 female individuals) with FLD were included in this study, of whom 19 (54.
Background: The adoption of Robotic Pancreaticoduodenectomy (RPD) is increasing globally. Meanwhile, reduced-port RPD (RPRPD) remains uncommon, requiring robot-specific techniques not possible with laparoscopy. We introduce a unique RPRPD technique optimizing surgical field exposure.
View Article and Find Full Text PDFBackground: The outcomes after liver transplantation have greatly improved, which has resulted in greater focus on improving non-hepatic outcomes of liver transplantation. The present study aimed to evaluate thoracic spine radio density in children and adolescents after liver transplantation.
Methods: A total of 116 patients who underwent living donor liver transplantation were retrospectively analyzed.
The liver and pancreas work together to recover homeostasis after hepatectomy. This study aimed to investigate the effect of liver resection volume on the pancreas. We collected clinical data from 336 living liver donors.
View Article and Find Full Text PDFArticle Synopsis
- COACH syndrome is a rare genetic disorder causing liver fibrosis and related complications, prompting the need for liver transplantation (LT) in affected patients.
- This study reports the outcomes of 4 female children who underwent LT for COACH syndrome, all experiencing severe portal hypertension and various degrees of renal impairment.
- The findings suggest that LT is an effective treatment for severe portal hypertension in COACH syndrome, although ongoing monitoring of renal function post-transplant is essential.
Article Synopsis
- Gallstone ileus (GI) is a rare type of bowel obstruction that occurs in less than 0.1% of cases and has been reported following certain surgeries, including liver transplantation (LT).
- A 33-year-old woman, who had previously undergone LT for biliary atresia, experienced sudden abdominal pain and nausea, leading to the discovery of a 4-cm gallstone causing an obstruction.
- Early diagnosis and intervention in cases of GI, even long after LT, are crucial to prevent serious complications and protect liver graft function.
Aim: We report a successful liver transplantation (LT) in a child with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Case Presentation: A 3-year-old female patient with decompensated cirrhosis due to Alagille syndrome underwent a split LT with a left lateral segment graft. She had a history of SARS-CoV-2 infection 4 months before LT.
Article Synopsis
- Surgical management of hepatoblastoma in children, especially when tumor thrombus extends into major vascular systems, presents unique challenges that are not extensively covered in existing literature.
- A study of 9 pediatric patients revealed that surgical strategies included liver resection and transplantation after preoperative chemotherapy, with varying results based on the type of vascular involvement.
- Overall, outcomes were favorable, with no patient deaths during follow-up, although a recurrence rate of 33.3% was observed, indicating the need for continued monitoring post-surgery.
Background: Repeat liver transplantation (LT) for patients with the liver graft failure who underwent metallic stent placement in the previous graft hepatic vein (HV) for HV complications can be very difficult. We retrospectively reviewed the safer surgical procedures during repeat LT for patients with a metallic stent in the graft HV.
Case Reports: Patient 1 with biliary atresia who was treated with metallic stent placement for HV stenosis underwent a third LT form a deceased donor at the age 17 years.
There is little information about the outcomes of pediatric patients with hepatolithiasis after living donor liver transplantation (LDLT). We retrospectively reviewed hepatolithiasis after pediatric LDLT. Between May 2001 and December 2020, 310 pediatric patients underwent LDLT with hepaticojejunostomy.
View Article and Find Full Text PDFBackground: Sinusoidal obstruction syndrome (SOS) after liver transplantation (LT) is a rare and potentially lethal complication. We retrospectively reviewed the outcomes of patients with post-transplant SOS.
Methods: Between May 2001 and December 2019, of 332 patients who underwent LT, 5 (1.
Background: There is no consensus about long-term outcomes in patients with biliary atresia. We retrospectively reviewed the long-term outcomes in pediatric patients who underwent living donor liver transplantation for biliary atresia.
Methods: Between May 2001 and December 2020, 221 (73%) of 302 pediatric patients who underwent living donor liver transplantation had biliary atresia.
Article Synopsis
- There is limited agreement on the long-term outcomes for children with inherited metabolic diseases (IMDs) undergoing living donor liver transplantation (LDLT), with a study reviewing 44 pediatric IMD patients illustrating key findings.
- The 10-year graft survival rates were high for both IMD and biliary atresia (BA) patients (87% and 94%, respectively), but patients with IMDs faced higher rates of complications like cytomegalovirus viremia.
- A significant portion of IMD patients experienced severe developmental issues, highlighting the need for ongoing support and educational resources for those affected.
Article Synopsis
- Patients with hepatitis-associated aplastic anemia (HAA) face serious risks like infections and bleeding after living-donor liver transplantation (LDLT).
- Rapid recovery of blood cells is essential to avoid these complications, and while immunosuppressive therapy (IST) is effective, its combination with thrombopoietin receptor agonists hasn't been well-studied for HAA.
- A case of a child with severe HAA showed successful and quick blood cell recovery after receiving IST with romiplostim, suggesting this combination could be a beneficial treatment for HAA patients post-LDLT.
Maternal T cells from perinatal transplacental passage have been identified in up to 40% of patients with severe combined immunodeficiency (SCID). Although engrafted maternal T cells sometimes injure newborn tissue, liver failure due to maternal T cells has not been reported. We rescued a boy with X-linked SCID who developed liver failure due to engrafted maternal T cell invasion following living donor liver transplantation (LDLT) following unrelated umbilical cord blood transplantation (UCBT).
View Article and Find Full Text PDFBackground: Complications associated with ultrasonographically guided percutaneous transhepatic liver biopsy (PTLB) after liver transplantation (LT) have been rarely reported, and there is no consensus about its safety. We retrospectively reviewed the safety and outcomes of PTLB after pediatric LT.
Methods: Between January 2008 and December 2019, 8/1122 (0.
Background: Myotubular myopathy is a rare disease sometimes accompanied by peliosis hepatis, a leading cause of fatal liver hemorrhage.
Case Report: We present a case of a 2-year-old boy with myotubular myopathy who developed liver hemorrhage because of peliosis hepatis and was successfully treated with living-donor liver transplant. The patient initially presented with fever, anemia, and liver dysfunction.
Liver Transplant for Posthepatectomy Liver Failure in Hepatoblastoma.
Exp Clin Transplant
October 2020
Objectives: Predicting the risk of posthepatectomy liver failure is important when performing extended hepatectomy. However, there is no established method to evaluate liver function and improve preoperative liver function in pediatric patients.
Materials And Methods: We show the clinical features of pediatric patients who underwent living donor liver transplant for posthepatectomy liver failure in hepatoblastoma.
Background: There have been no reports on the effectiveness of the administration of antithrombin III (AT III) for post-transplant portal vein thrombosis (PVT). We herein report a case of post-transplant PVT that was resolved by AT III treatment after living donor liver transplantation (LDLT).
Case Presentation: The patient was a 57-year-old man who had been diagnosed with decompensate liver cirrhosis by hepatitis C virus infection.
BACKGROUND The number of pregnancies after liver transplantation (LT) is increasing; however, the safety and incidence of complications associated with these pregnancies are still unclear. In this report, we retrospectively assessed the influences and problems associated with post-transplant pregnancy on allografts, recipients, and fetuses. MATERIAL AND METHODS A total of 14 pregnancies were identified in 8 female recipients between 2005 and 2018.
View Article and Find Full Text PDFPurpose: Advances in interventional radiology (IVR) treatment have notably improved the prognosis of hepatic vein (HV) and portal vein (PV) complications following pediatric living donor liver transplantation (LDLT); however, graft failure may develop in refractory cases. Although endovascular stent placement is considered for recurrent stenosis, its indications are controversial.
Methods: We enrolled 282 patients who underwent pediatric LDLT in our department from May 2001 to September 2016.
Background: We present a retrospective analysis of our experience with pediatric liver transplantation (LT), focusing on the long-term outcome of percutaneous transhepatic biliary drainage (PTBD) for post-transplant biliary strictures.
Methods: Fifty-three PTBDs were performed for 41 pediatric recipients with biliary strictures. The median ages at LT and PTBD were 1.
Article Synopsis
- Early relaparotomy (surgical intervention within 3 months post-transplant) in pediatric liver transplant recipients is linked to worse survival outcomes compared to those who don't undergo this procedure.
- The study analyzed 265 pediatric liver transplant cases and found that 12.5% required early relaparotomy, which resulted in significantly lower recipient and graft survival rates.
- A higher preoperative Pediatric End-Stage Liver Disease (PELD) score was associated with the need for early relaparotomy, particularly in cases where the intervention was due to infections, which had the poorest prognosis.
Background: We present retrospective analysis of our 15-year experience with pediatric living donor liver transplantation, focusing on the risk factors, treatments, and long-term prognosis for posttransplant biliary complications (BCs).
Methods: Between May 2001 and December 2017, 290 living donor liver transplantations were performed. The median age was 1.