Publications by authors named "Noriki Fujimoto"
Article Synopsis
- Japan has reported cases of Buruli ulcer (BU), a rare disease caused by Mycobacterium ulcerans subsp. shinshuense, dating back to 1982, with an increase in cases, especially in the last decade.
- Out of 87 total reported cases to date, 50 occurred within the last ten years, indicating a rising trend.
- The country's advanced healthcare system aids in the investigation and treatment of BU, but a lack of awareness among medical professionals often leads to delayed diagnoses, highlighting the need for increased education and awareness efforts.
Introduction: Regression of malignant melanoma (MM) is a commonly observed phenomenon, which refers to disappearance or loss of all or part of MM. It can be identified both clinically and histologically, and high probability of histological regression of MM (10-58%) has been reported. However, the decapitation of skin tumor has rarely been described in the English literature, and decapitation in MM has not been reported.
View Article and Find Full Text PDFObjectives: There is a lack of quantitative and objective methods for measuring skin hardness. This study aimed to verify whether SOFTGRAM, a device that can measure elastic modulus using the Hertz elastic contact theory, could be used to evaluate skin hardness in systemic sclerosis (SSc).
Methods: Skin score according to the modified Rodnan total skin thickness score and elastic modulus of the skin using SOFTGRAM were measured for 20 patients with SSc and 20 healthy controls on 8 parts of the body, both of the cheeks, forearms, fingers, and hands.
Article Synopsis
- The study focused on the effectiveness of salvage therapies in Japanese patients with advanced acral melanoma (AM) after they failed PD-1 monotherapy, a common treatment for melanoma.
- 108 patients were analyzed, receiving various treatments such as ipilimumab, nivolumab plus ipilimumab, or cytotoxic chemotherapy, with varying objective response rates (ORR) and overall survival (OS) outcomes.
- Results indicated that while the combination of nivolumab and ipilimumab showed the longest median OS, it was not significantly more effective than other treatments, and nail apparatus melanoma patients had poorer survival outcomes compared to those with palm and sole melanoma.
The association between immunoregulatory cytokines, such as interleukin (IL)-10 or IL-35, and dipeptidyl peptidase-4 inhibitor (DPP4i)-related bullous pemphigoid (BP) has not been evaluated. Serum IL-10 and IL-35 levels were measured in 39 patients with BP (24 males and 15 females; 6 DPP4i-related and 33 DPP4i-unrelated BP patients) and 10 healthy controls. The number of CD26 cells in the dermis around bulla on sections was counted immunohistochemically for 12 patients (six patients with DPP4i-related BP and six randomly sampled patients with DPP4i-unrelated BP).
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