Publications by authors named "Noriaki Oguri"
Akkermansia muciniphila in the small intestine improves liver fibrosis in a murine liver cirrhosis model.
NPJ Biofilms Microbiomes
September 2024
Article Synopsis
- * The antibiotic rifaximin (RFX) has been found to improve liver fibrosis and hyperammonemia in a murine model of LC, while also changing the composition of gut bacteria, particularly increasing levels of the beneficial genus Akkermansia.
- * The research presents the idea of a "small intestine-liver axis," proposing that administering the bacteria Akkermansia muciniphila could be a promising new treatment strategy for liver complications related to cirrhosis.
Although many therapeutic options are available for inflammatory bowel disease (IBD), 5-aminosalicylic acid (5-ASA) is still the key medication, particularly for ulcerative colitis (UC). However, the mechanism of action of 5-ASA remains unclear. The intestinal microbiota plays an important role in the pathophysiology of IBD, and we hypothesized that 5-ASA alters the intestinal microbiota, which promotes the anti-inflammatory effect of 5-ASA.
View Article and Find Full Text PDFBackground And Aim: Endoscopic band ligation (EBL), used for the treatment of colonic diverticular bleeding, has a lower rebleeding rate than endoscopic clipping. However, different devices are used in Japan and the Western countries; no animal studies have been conducted to elucidate the safety of such devices. We compared two EBL devices, the first used in Japan and the second used in Western countries.
View Article and Find Full Text PDFThe rate of early rebleeding after endoscopic submucosal dissection (ESD) for early gastric cancer ranges from 5 % to 38 %, despite application of preventive methods. Post-ESD rebleeding may be caused by "invisible" vessels that may not be detectable using ultrasonographic techniques. Recently, Doppler probe ultrasonography (DOP) has been used in endoscopy.
View Article and Find Full Text PDFBackground And Aims: The identification of stigmata of recent hemorrhage (SRH) in colonic diverticular bleeding (CDB) enables an endoscopic treatment and can improve the clinical outcome. However, SRH identification rate remains low. This study aims to investigate whether NOBLADS and Strate scoring systems are useful for predicting SRH identification rate of CDB pre-procedurally via colonoscopy.
View Article and Find Full Text PDFArticle Synopsis
- A 46-year-old woman in Japan developed severe community-acquired fulminant colitis due to Clostridium difficile, leading to her transfer for intensive care after her condition worsened with toxic megacolon and respiratory issues.
- She underwent intubation and treatment with antibiotics, ultimately recovering and being discharged without lasting effects.
- The specific strain identified was a rare binary toxin-producing C. difficile, different from the more common strains seen in epidemics elsewhere, highlighting the need for more research on community-acquired CDI in Japan.