Publications by authors named "Noriaki Moriyama"

Background: Vascular and bleeding complications remain a concern after transfemoral transcatheter aortic valve replacement (TAVR). The impact of the sheath type on these complications remains unclear.

Methods: The prospective MARVEL registry study analyzed enrolled 500 patients undergoing large-bore transfemoral procedures and arteriotomy closure with the MANTA vascular closure device from 10 hospitals in Europe and Canada.

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Background/purpose: Transcatheter aortic valve replacement (TAVR) with ACURATE neo2 showed better hemodynamic outcomes by mitigating paravalvular leakage (PVL) compared with ACURATE neo, and revealed promising one-year outcomes in single-arm studies. However, studies comparing the hemodynamic and clinical outcomes of the two valves are still scarce. Therefore, this study aimed to compare the one-year hemodynamic and clinical outcomes between the neo2 and neo.

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  • The study analyzes the outcomes of 4,523 patients who underwent transcatheter aortic valve implantation (TAVI) for severe aortic stenosis, categorized into three groups based on flow gradient patterns: high-gradient AS (HG-AS), classical low-flow low-gradient AS (cLFLG-AS), and paradoxical low-flow low-gradient AS (pLFLG-AS).
  • Results indicated that cLFLG-AS and pLFLG-AS had about 1.5 times higher two-year all-cause mortality rates compared to HG-AS, with cLFLG-AS showing more significant improvements in heart structure and function post-procedure.
  • Specifically, cLFLG-AS patients experienced a greater reduction in left ventricular
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  • This study explores how predicted prosthesis-patient mismatch (PPM) affects health outcomes in patients who underwent transcatheter aortic valve replacement (TAVR), with a focus on five-year results.
  • It analyzed data from 1,733 patients, measuring PPM using different methods, and found that while PPM rates were low, they had a significant relationship with adverse clinical outcomes in those with reduced left ventricular ejection fraction (LVEF).
  • Overall, the findings suggest that PPM should be a consideration in TAVR patients, especially those with low LVEF, as it may lead to worse long-term health outcomes.
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  • SGLT2 inhibitors (SGLT2is) are effective in treating acute coronary syndrome (ACS) and their impact on unstable coronary plaque is being studied in patients with type 2 diabetes.* -
  • The study analyzed data from 109 patients, comparing those treated with SGLT2is to those who were not, focusing on changes in coronary plaque using optical coherence tomography (OCT) images.* -
  • Results showed that SGLT2is significantly improved plaque stability and reduced the incidence of major cardiovascular events compared to the non-SGLT2i group.*
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Preexisting right bundle branch block (RBBB) is the strongest predictor for permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation (TAVI). However, the risk assessment for new PPI and effective procedural strategy for preventing new PPI in patients with preexisting RBBB are still unclear. This study stratified the new PPI risk after TAVI and investigated the impact of implantation strategy in a preexisting RBBB cohort.

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Background: Transcatheter aortic valve implantation (TAVI) is an established treatment for severe aortic stenosis (AS), but despite estimates of life expectancy after TAVI being essential in heart team discussion, these data are scarce. Therefore, the current study sought to assess long-term survival and its trends in relation to chronological age, surgical risk, and treatment period.

Methods and results: We included 2,414 consecutive patients who underwent TAVI for severe symptomatic AS between 2008 and 2021 at 2 international centers.

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  • The study investigates the optimal percent oversizing (%OS) for the SAPIEN3 Ultra (S3U) transcatheter aortic valve to minimize paravalvular regurgitation (PVR) while assessing the risk of conduction disturbances (CD).
  • It compared 350 patients with the S3U against 606 patients using the original SAPIEN3 (S3), finding significantly lower rates of PVR in the S3U group across various %OS levels.
  • The findings suggest that a minimal %OS (0% to 5%) is optimal for the S3U, balancing the risks of PVR and CD more effectively than the S3.
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Membranous septum (MS) length, in conjunction with implantation depth (ID), is known as a determinant of conduction disturbance (CD) after transcatheter aortic valve implantation (TAVI). However, its impact might be dissimilar among valve types because each valve has a different platform. This study sought to investigate the different impacts of ID and MS length on the new-onset CD between ACURATE neo and SAPIEN 3.

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Background: Transcatheter aortic valve replacement (TAVR) has become the dominant treatment strategy for severe aortic stenosis in patients with high and intermediate surgical risk. Although complications are significant cause of increasing mortality after TAVR and bailout techniques have been well established, we still encounter a rare complication without widely accepted bailout option. We present a rare complication of valvuloplasty balloon entrapment to a self-expanding valve strut with successful bailout.

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  • The study investigates how high transcatheter heart valve (THV) implantation affects coronary access after transcatheter aortic valve replacement (TAVR), using postimplantation CT scans.
  • It compares two types of THVs (Evolut R/PRO/PRO+ and SAPIEN 3) across different implantation techniques, finding that high implantation reduces conduction disturbances for both devices.
  • Despite this benefit, the high implantation technique was associated with a higher risk of THV skirt interference with coronary ostia access and increased risk of sinus sequestration in cases requiring TAVR-in-TAVR.
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The impact of mild paravalvular regurgitation (PVR) after transcatheter aortic valve implantation (TAVI) remains controversial. We evaluated the impact of mild PVR after TAVI on long-term clinical outcomes. We included patients who underwent TAVI for severe symptomatic aortic stenosis between December 2008 and June 2019 at 2 international centers and compared all-cause death between the group with mild PVR (group 1) and the group with none or trace PVR (group 2).

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Background: One-third of patients undergoing transcatheter aortic valve implantation (TAVI) have an indication for long-term oral anticoagulation (OAC).

Aims: We aimed to investigate whether continued non-vitamin K antagonist oral anticoagulant (NOAC) therapy compared with continued vitamin K antagonist (VKA) therapy during TAVI is equally safe and effective.  Methods: Consecutive patients on OAC with either NOAC or VKA undergoing transfemoral TAVI at five European centres were enrolled.

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  • This study focused on whether zinc supplementation, specifically using zinc acetate hydrate, could help improve renal anemia in patients on hemodialysis with low zinc levels.
  • It involved 21 patients over 6 months, measuring changes in zinc levels and erythropoietin resistance (ERI) to assess the impact of the supplementation.
  • Results showed that zinc levels increased significantly, while the need for erythropoiesis-stimulating agents and ERI decreased, indicating that correcting low zinc levels may benefit renal anemia management.
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Unlabelled: The indications for transfemoral transcatheter aortic valve replacement (TAVR) have been expanding; however, treatment protocol for patients with severe aortic stenosis with other significant valve disease is still controversial. Furthermore, there are few randomized data to guide therapy in multivalvular disease. We describe a successful percutaneous transvenous mitral commissurotomy and TAVR simultaneously.

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Background: Comparisons of hemodynamic results between ACURATE Neo and ACURATE Neo 2, which have updated outer sealing skirts, are limited. This retrospective study aimed to demonstrate the differences in hemodynamic outcomes between the two transcatheter heart valves (THVs).

Methods: We included 449 patients who underwent transfemoral transcatheter aortic valve replacement (TAVR) with either ACURATE Neo2 (n = 100) or ACURATE Neo (n = 348) between January 2016 and November 2021.

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  • * Researchers examined 140 patients with severe AS, analyzing a total of 164 vascular segments and categorizing them into four groups based on their FFR and iFR measurements.
  • * They found that 29.3% of cases exhibited discordance, predominantly negative discordance (where iFR is lower but FFR is higher), particularly in the left anterior descending artery and when peak velocity was 5.0 m/s or more.
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Despite the development of device technology and operators' experience, access site vascular complications (VCs) remain one of the major concerns after transcatheter aortic valve implantation (TAVI). MANTA (Teleflex, Wayne, Pennsylvania) is a large-bore vascular closure device (VCD) with promising incidence of VC. Previously, we demonstrated that the ultrasound-guided MANTA (US-MANTA) technique further improved the outcomes compared with conventional MANTA (C-MANTA) without ultrasound guidance.

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Objectives: Although a distal radial artery (DRA) approach has recently been used in patients undergoing cardiac catheterization, no studies have so far investigated the safety and feasibility of DRA in patients undergoing hemodialysis (HD). We aimed to investigate the incidence of conventional radial artery (CRA) occlusion and puncture site complications after DRA puncture in patients undergoing HD.

Methods: We retrospectively analyzed the data of 117 consecutive patients with HD who underwent coronary angiography or percutaneous coronary intervention via a DRA approach at our institution from September 2017 to December 2019.

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Superior vena cava laceration has been reported as a catastrophic complication that requires immediate surgical intervention during transvenous lead extraction. Hereby, we present 2 cases of pseudoaneurysm formation at the superior vena cava after transvenous lead extraction, which were successfully managed without invasive treatment. ().

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Recent studies showed the favorable outcomes of transcatheter aortic valve implantation (TAVI) in patients with bicuspid aortic valve (BAV) stenosis. However, data on the relation between BAV morphology and optimal transcatheter heart valve (THV) selection are limited. This study sought to evaluate the determinants of device performance in patients with BAV who underwent TAVI.

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Introduction: Implantation depth and membranous septum (MS) length have been established as the predictors of new-onset conduction disturbance (CD) after transcatheter aortic valve replacement (TAVR) for tricuspid aortic valve (TAV) stenosis. However, little is known about the predictors with bicuspid aortic valve (BAV). This study investigated the role of MS length and implantation depth in predicting CD following TAVR with a balloon-expandable valve in patients with BAV.

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